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Article

Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties

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Faculty of Pharmacy of University of Coimbra, University of Coimbra, 3000-548 Coimbra, Portugal
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LAQV, REQUIMTE, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
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Center for Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
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CIEPQPF, Research Center for Chemical Processes Engineering and Forest Products, University of Coimbra, 3030-790 Coimbra, Portugal
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Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
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Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal
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PhD Trials, Avenida Maria Helena Vieira da Silva, nº 24 A, 1750-182 Lisbon, Portugal
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Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(2), 154; https://doi.org/10.3390/antiox9020154
Received: 15 January 2020 / Revised: 11 February 2020 / Accepted: 12 February 2020 / Published: 14 February 2020
(This article belongs to the Special Issue Antioxidants and Skin Protection)
Fragaria vesca L. (F. vesca), popularly known as wild strawberry, is a plant from the Rosaceae family, found in temperate and subtropical areas of the northern hemisphere. F. vesca leaves have been shown to have antiseptic, emollient, and dermatological protection properties, due to the presence of bioactive compounds, such as flavonoids, phenolic acids, ellagitannins, and proanthocyanidins. In this study, a F. vesca extract was obtained by an optimized extraction process, and was characterized by HPLC, ROS scavenging activity, cytotoxicity assays in HaCaT cells, and tyrosinase inhibitory activity determination. The most active extract was then incorporated in a hydrogel with hydroxyethylcellulose at 2% (w/w), which was characterized at the physicochemical, stability, cytotoxicity, and ROS scavenging activity levels to evaluate its quality, safety, and efficacy. In vivo studies, human repeat insult patch testing, and an assay to determine their antioxidant efficacy, were also performed. The results showed that the Fragaria vesca extracts had antioxidant activity and that the F. vesca extract-based hydrogel exhibited cutaneous compatibility, acceptability and antioxidant efficacy, being stable, and suitable for topical application. View Full-Text
Keywords: Fragaria vesca L.; antioxidant properties; hydrogel; topical application; cutaneous compatibility Fragaria vesca L.; antioxidant properties; hydrogel; topical application; cutaneous compatibility
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MDPI and ACS Style

Couto, J.; Figueirinha, A.; Batista, M.T.; Paranhos, A.; Nunes, C.; Gonçalves, L.M.; Marto, J.; Fitas, M.; Pinto, P.; Ribeiro, H.M.; Pina, M.E. Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties. Antioxidants 2020, 9, 154. https://doi.org/10.3390/antiox9020154

AMA Style

Couto J, Figueirinha A, Batista MT, Paranhos A, Nunes C, Gonçalves LM, Marto J, Fitas M, Pinto P, Ribeiro HM, Pina ME. Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties. Antioxidants. 2020; 9(2):154. https://doi.org/10.3390/antiox9020154

Chicago/Turabian Style

Couto, Joana, Artur Figueirinha, Maria T. Batista, António Paranhos, Carla Nunes, Lídia M. Gonçalves, Joana Marto, Manuel Fitas, Pedro Pinto, Helena M. Ribeiro, and Maria E. Pina 2020. "Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties" Antioxidants 9, no. 2: 154. https://doi.org/10.3390/antiox9020154

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