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Open AccessArticle

Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties

1
Department of Pharmaceutical Botany, University of Medicine, Pharmacy, Sciences and Technology, 540139 Târgu Mureș, Romania
2
Department of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca 400337, Romania
3
Department of Medical Devices, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca 400439, Romania
4
Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
5
Department of Analytical chemistry and Drug analysis, University of Medicine, Pharmacy, Sciences and Technology “, 540139 Târgu Mureș, Romania
6
Department of Organic Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
These authors share the first authorship.
Antioxidants 2019, 8(9), 417; https://doi.org/10.3390/antiox8090417
Received: 14 August 2019 / Revised: 9 September 2019 / Accepted: 9 September 2019 / Published: 19 September 2019
The present study aimed, on the one hand, to improve the yield of microwave assisted extraction (MAE) of polyphenols from beech bark by using a design of experiments (DoE) approach. On the other hand, beech bark extracts (BBE) were characterized in terms of their phytochemical profile and evaluated for biological potential (antioxidant, antibacterial, antifungal, antimutagen, anti-α-glucosidase, and anti-tyrosinase). The extraction time varies with the amount of extracted total phenolic content (TPC). The microwave power favors TPC extraction but in different proportions. The optimum conditions which gave the highest TPC (76.57 mg GAE/g dry plant material) were reached when the microwave power was 300 W, extraction time was 4 min, and the solvent was an ethanol–water (50:50) mixture. The practical value of TPC after a controlled experiment was 76.49 mg GAE/g plant material. The identified compounds were vanillic acid, gallic acid, epicatechin, catechin, protocatechuic acid, chlorogenic acid, ferulic acid, and isoquercitrin. The antioxidant potential of BBEs was demonstrated by in vitro experiments. The BBEs were active against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, and Candida species. All extracts were antimutagenic and expressed an inhibition on α-glucosidase and tyrosinase activity. Regarding antimutagen activity, the assayed extracts may be considered to have low or no antimutagen effects. View Full-Text
Keywords: antioxidant; antibacterial; antifungal; antimutagen; anti-α-glucosidase; anti-tyrosinase; beech bark; microwave assisted extraction; optimization antioxidant; antibacterial; antifungal; antimutagen; anti-α-glucosidase; anti-tyrosinase; beech bark; microwave assisted extraction; optimization
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Tanase, C.; Mocan, A.; Coșarcă, S.; Gavan, A.; Nicolescu, A.; Gheldiu, A.-M.; Vodnar, D.C.; Muntean, D.-L.; Crișan, O. Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties. Antioxidants 2019, 8, 417.

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