Evaluation of the Antioxidant Activity of Cis/Trans-N-Phenyl-1,4,4a,5,8,8a-Hexahydro-3,1-Benzoxazin-2-Imines
AbstractThe growing interest in the chemistry of unsaturated ring-fused 1,3-heterocycles, in this particular case 1,3-oxazines, arise in part from their versatile pharmacological applications. In the present article, the evaluation of the in vitro and ex vivo antioxidant activity of two cyclohexene-fused oxazines is discussed. The in vitro antioxidant activity was evaluated by trapping the ABTS and hydroxyl radicals as well as the inhibition of the enzyme acetyl-cholinesterase and hemolysis of erythrocytes by 2,2’-Azobis(2-amidinopropane) dihydrochloride (AAPH). The results suggest that both unsaturated 1,3-oxazines are auspicious sources of biologically active compounds with good antioxidant properties. In addition, a comprehensive analysis of the interaction between these heterocycles with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals, as well as the measurements of redox potential, provided evidence for a mechanism of antioxidant activity that takes place through electron transfer (ET) processes. View Full-Text
Share & Cite This Article
Firpo, G.; Ramírez, M.L.; Faillace, M.S.; de Brito, M.R.M.; e Silva, A.P.S.C.L.; Costa, J.P.; Rodríguez, M.C.; Argüello, G.A.; Szakonyi, Z.; Fülöp, F.; Peláez, W.J. Evaluation of the Antioxidant Activity of Cis/Trans-N-Phenyl-1,4,4a,5,8,8a-Hexahydro-3,1-Benzoxazin-2-Imines. Antioxidants 2019, 8, 197.
Firpo G, Ramírez ML, Faillace MS, de Brito MRM, e Silva APSCL, Costa JP, Rodríguez MC, Argüello GA, Szakonyi Z, Fülöp F, Peláez WJ. Evaluation of the Antioxidant Activity of Cis/Trans-N-Phenyl-1,4,4a,5,8,8a-Hexahydro-3,1-Benzoxazin-2-Imines. Antioxidants. 2019; 8(6):197.Chicago/Turabian Style
Firpo, Guadalupe; Ramírez, María L.; Faillace, Martín S.; de Brito, Maria R.M.; e Silva, Ana P.S.C.L.; Costa, Jessica P.; Rodríguez, Marcela C.; Argüello, Gustavo A.; Szakonyi, Zsolt; Fülöp, Ferenc; Peláez, Walter J. 2019. "Evaluation of the Antioxidant Activity of Cis/Trans-N-Phenyl-1,4,4a,5,8,8a-Hexahydro-3,1-Benzoxazin-2-Imines." Antioxidants 8, no. 6: 197.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.