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Keywords = unsaturated-fused 1,3-oxazines

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14 pages, 2268 KiB  
Article
Evaluation of the Antioxidant Activity of Cis/Trans-N-Phenyl-1,4,4a,5,8,8a-Hexahydro-3,1-Benzoxazin-2-Imines
by Guadalupe Firpo, María L. Ramírez, Martín S. Faillace, Maria dos R. Mendes de Brito, Ana P. S. Correia Lima e Silva, Jessica Pereira Costa, Marcela C. Rodríguez, Gustavo A. Argüello, Zsolt Szakonyi, Ferenc Fülöp and Walter J. Peláez
Antioxidants 2019, 8(6), 197; https://doi.org/10.3390/antiox8060197 - 25 Jun 2019
Cited by 13 | Viewed by 4800
Abstract
The growing interest in the chemistry of unsaturated ring-fused 1,3-heterocycles, in this particular case 1,3-oxazines, arise in part from their versatile pharmacological applications. In the present article, the evaluation of the in vitro and ex vivo antioxidant activity of two cyclohexene-fused oxazines is [...] Read more.
The growing interest in the chemistry of unsaturated ring-fused 1,3-heterocycles, in this particular case 1,3-oxazines, arise in part from their versatile pharmacological applications. In the present article, the evaluation of the in vitro and ex vivo antioxidant activity of two cyclohexene-fused oxazines is discussed. The in vitro antioxidant activity was evaluated by trapping the ABTS and hydroxyl radicals as well as the inhibition of the enzyme acetyl-cholinesterase and hemolysis of erythrocytes by 2,2’-Azobis(2-amidinopropane) dihydrochloride (AAPH). The results suggest that both unsaturated 1,3-oxazines are auspicious sources of biologically active compounds with good antioxidant properties. In addition, a comprehensive analysis of the interaction between these heterocycles with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals, as well as the measurements of redox potential, provided evidence for a mechanism of antioxidant activity that takes place through electron transfer (ET) processes. Full article
(This article belongs to the Special Issue The Chemistry of Antioxidant Activity)
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