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Open AccessArticle

Correction of Experimental Retinal Ischemia by l-Isomer of Ethylmethylhydroxypyridine Malate

Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, Belgorod 308015, Russia
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Antioxidants 2019, 8(2), 34; https://doi.org/10.3390/antiox8020034
Received: 12 December 2018 / Revised: 26 January 2019 / Accepted: 30 January 2019 / Published: 3 February 2019
(This article belongs to the Special Issue Antioxidants and Retinal Disease)
An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative–l-isomer of ethylmethylhydroxypyridine malate. A modification to the retinal ischemia-reperfusion model was used, in which an increase in intraocular pressure is carried out by mechanical pressure (110 mmHg) to the front chamber of the eye for 30 min. The protective effects of l-isomer of ethylmethylhydroxypyridine malate in comparison with Emoxipine as pretreatment, with parabulbar injection, based on the model of retinal ischemia-reperfusion, were estimated by the changes in the ratio of the amplitudes of the a- and b-waves of electroretinography (the b/a coefficient) and ophthalmoscopy. The use of l-isomer of ethylmethylhydroxypyridine malate improves the retinal electrophysiological state after 72 h of reperfusion; in the group of rats treated with l-isomer of ethylmethylhydroxypyridine malate, the coefficient b/a was reliably increased by 9.5%, p < 0.05, in comparison with animals treated with Emoxipine, and by 91.7%, p < 0.05, in comparison with the group with no treatment. Furthermore, it prevents the development of ischemic changes in the retina observed in ophthalmoscopy to a greater extent than Emoxipine. View Full-Text
Keywords: retinal ischemia; l-isomer of ethylmethylhydroxypyridine malate; Emoxipine; b/a coefficient; Wistar rats retinal ischemia; l-isomer of ethylmethylhydroxypyridine malate; Emoxipine; b/a coefficient; Wistar rats
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Peresypkina, A.; Pazhinsky, A.; Pokrovskii, M.; Beskhmelnitsyna, E.; Pobeda, A.; Korokin, M. Correction of Experimental Retinal Ischemia by l-Isomer of Ethylmethylhydroxypyridine Malate. Antioxidants 2019, 8, 34.

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