Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, Donald G; Caruso, Maya; Murchison, Charles F; Zhu, Jennifer Y; Wright, Kirsten M; Harris, Christopher J; Gray, Nora E; Quinn, Joseph F; Soumyanath, Amala

doi:10.3390/antiox8120630

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Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

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Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA

Parkinson’s Disease Research Education and Clinical Care Center, Veterans’ Administration Portland Health Care System, Portland, OR 97239, USA

Author to whom correspondence should be addressed.

Antioxidants 2019, 8(12), 630; https://doi.org/10.3390/antiox8120630

Received: 30 October 2019 / Revised: 3 December 2019 / Accepted: 6 December 2019 / Published: 8 December 2019

(This article belongs to the Special Issue Botanical Antioxidants and Neurological Diseases)

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Abstract

Centella asiatica (CA) herb is a traditional medicine, long reputed to provide cognitive benefits. We have reported that CA water extract (CAW) treatment improves cognitive function of aged Alzheimer’s disease (AD) model Tg2576 and wild-type (WT) mice, and induces an NRF2-regulated antioxidant response in aged WT mice. Here, CAW was administered to AD model 5XFAD female and male mice and WT littermates (age: 7.6 +/

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0.6 months), and object recall and contextual fear memory were tested after three weeks treatment. CAW’s impact on amyloid-β plaque burden, and markers of neuronal oxidative stress and synaptic density, was assessed after five weeks treatment. CAW antioxidant activity was evaluated via nuclear transcription factor (erythroid-derived 2)-like 2 (NRF2) and NRF2-regulated antioxidant response element gene expression. Memory improvement in both genders and genotypes was associated with dose-dependent CAW treatment without affecting plaque burden, and marginally increased synaptic density markers in the hippocampus and prefrontal cortex. CAW treatment increased Nrf2 in hippocampus and other NRF2 targets (heme oxygenase-1, NAD(P)H quinone dehydrogenase 1, glutamate-cysteine ligase catalytic subunit). Reduced plaque-associated SOD1, an indicator of oxidative stress, was observed in the hippocampi and cortices of CAW-treated 5XFAD mice. We postulate that CAW treatment leads to reduced oxidative stress, contributing to improved neuronal health and cognition. View Full-Text

Keywords: Centella asiatica; Alzheimer’s disease; 5XFAD; mouse model; oxidative stress; antioxidant; NRF2; neuritic dystrophy; cognitive function; memory

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Matthews, D.G.; Caruso, M.; Murchison, C.F.; Zhu, J.Y.; Wright, K.M.; Harris, C.J.; Gray, N.E.; Quinn, J.F.; Soumyanath, A. Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice. Antioxidants 2019, 8, 630. https://doi.org/10.3390/antiox8120630

AMA Style

Matthews DG, Caruso M, Murchison CF, Zhu JY, Wright KM, Harris CJ, Gray NE, Quinn JF, Soumyanath A. Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice. Antioxidants. 2019; 8(12):630. https://doi.org/10.3390/antiox8120630

Chicago/Turabian Style

Matthews, Donald G., Maya Caruso, Charles F. Murchison, Jennifer Y. Zhu, Kirsten M. Wright, Christopher J. Harris, Nora E. Gray, Joseph F. Quinn, and Amala Soumyanath. 2019. "Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice" Antioxidants 8, no. 12: 630. https://doi.org/10.3390/antiox8120630

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