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Review

The Drosophila Model: Exploring Novel Therapeutic Compounds against Neurodegenerative Diseases

1
Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan 31151, Korea
2
Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Korea
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(12), 623; https://doi.org/10.3390/antiox8120623
Received: 13 November 2019 / Revised: 4 December 2019 / Accepted: 5 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Botanical Antioxidants and Neurological Diseases)
Polyphenols are secondary metabolites of plants, fruits, and vegetables. They act as antioxidants against free radicals from UV light, pathogens, parasites, and oxidative stress. In Drosophila models, feeding with various polyphenols results in increased antioxidant capacity and prolonged lifespan. Therefore, dietary polyphenols have several health advantages for preventing many human diseases, including cardiovascular diseases, cancer, and neurodegenerative diseases. However, the exact role of polyphenols in neurodegenerative diseases is still yet to be completely defined. This review focuses on the most recent studies related to the therapeutic effect of polyphenols in neurodegenerative disease management and provides an overview of novel drug discovery from various polyphenols using the Drosophila model. View Full-Text
Keywords: polyphenol; antioxidant; Drosophila melanogaster; neurodegenerative disease polyphenol; antioxidant; Drosophila melanogaster; neurodegenerative disease
MDPI and ACS Style

Cha, S.J.; Do, H.-A.; Choi, H.-J.; Lee, M.; Kim, K. The Drosophila Model: Exploring Novel Therapeutic Compounds against Neurodegenerative Diseases. Antioxidants 2019, 8, 623. https://doi.org/10.3390/antiox8120623

AMA Style

Cha SJ, Do H-A, Choi H-J, Lee M, Kim K. The Drosophila Model: Exploring Novel Therapeutic Compounds against Neurodegenerative Diseases. Antioxidants. 2019; 8(12):623. https://doi.org/10.3390/antiox8120623

Chicago/Turabian Style

Cha, Sun J., Hyeon-Ah Do, Hyun-Jun Choi, Mihye Lee, and Kiyoung Kim. 2019. "The Drosophila Model: Exploring Novel Therapeutic Compounds against Neurodegenerative Diseases" Antioxidants 8, no. 12: 623. https://doi.org/10.3390/antiox8120623

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