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Open AccessReview

Nitrosative Stress in Retinal Pathologies: Review

1
Departamento Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 64315 Valencia, Spain
2
Departamento de Ciencias Biomédicas, Universidad Europea de Valencia, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(11), 543; https://doi.org/10.3390/antiox8110543
Received: 15 September 2019 / Revised: 30 October 2019 / Accepted: 6 November 2019 / Published: 11 November 2019
(This article belongs to the Special Issue Antioxidants and Retinal Disease)
Nitric oxide (NO) is a gas molecule with diverse physiological and cellular functions. In the eye, NO is used to maintain normal visual function as it is involved in photoreceptor light transduction. In addition, NO acts as a rapid vascular endothelial relaxant, is involved in the control of retinal blood flow under basal conditions and mediates the vasodilator responses of different substances such as acetylcholine, bradykinin, histamine, substance P or insulin. However, the retina is rich in polyunsaturated lipid membranes and is sensitive to the action of reactive oxygen and nitrogen species. Products generated from NO (i.e., dinitrogen trioxide (N2O3) and peroxynitrite) have great oxidative damaging effects. Oxygen and nitrogen species can react with biomolecules (lipids, proteins and DNA), potentially leading to cell death, and this is particularly important in the retina. This review focuses on the role of NO in several ocular diseases, including diabetic retinopathy, retinitis pigmentosa, glaucoma or age-related macular degeneration (AMD). View Full-Text
Keywords: nitric oxide; peroxynitrite; nitric oxide synthase; retina; diabetes; retinitis pigmentosa; glaucoma; age related macular degeneration nitric oxide; peroxynitrite; nitric oxide synthase; retina; diabetes; retinitis pigmentosa; glaucoma; age related macular degeneration
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MDPI and ACS Style

Cantó, A.; Olivar, T.; Romero, F.J.; Miranda, M. Nitrosative Stress in Retinal Pathologies: Review. Antioxidants 2019, 8, 543.

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