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Open AccessArticle

Sideritis Perfoliata (Subsp. Perfoliata) Nutritive Value and Its Potential Medicinal Properties

Department of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa
School of Natural Resources, University of Missouri, Columbia, MO 65211, USA
College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India
Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, 3036 Lemesos, Cyprus
Authors to whom correspondence should be addressed.
Antioxidants 2019, 8(11), 521;
Received: 11 September 2019 / Revised: 24 October 2019 / Accepted: 25 October 2019 / Published: 30 October 2019
Sideritis perfoliata L. subsp. perfoliata is an endemic species of the Eastern Mediterranean region with several uses in traditional medicine. The present study aims to explore the unknown properties of S. perfoliata investigating the nutritional content as well as the antioxidant, anticancer, antituberculosis, antiwrinkle, anti-acne, hyper/hypo-pigmentation and antibacterial activities. Mineral content, nutritional value, the composition and antioxidant properties of the essential oil, the antityrosinase, the antibacterial activity and anti-elastase potential of the extract, were evaluated. The antiproliferative activity of S. perfoliata against cervical cancer (HeLa), human melanoma (UCT-Mel-1), human hepatocellular carcinoma (HepG2) and human epidermoid carcinoma (A431) was investigated. Cytotoxic effects on normal human keratinocyte (HaCat) and kidney epithelial (Vero) cell lines were also determined. Sideritis perfoliata exhibited high nutritional value of proteins and minerals (K, P, Mg, Fe, Zn, Cu). The most abundant components of the essential oil were found to be α-pinene, β-phelladrene, valeranone, β-pinene and sabinene. The ethanolic extract of S. perfoliata displayed moderate antioxidant potential and antibacterial activity against Prevotella intermedia. Noteworthy elastase and moderate anticancer potential against the human liver cancer cell line (HepG2) was observed with IC50 values of 57.18 ± 3.22 μg/mL and 64.27 ± 2.04 μg/mL respectively. The noteworthy in vitro activity of S. perfoliata could be due to the presence of flavonoids and phenols in the leaves, having high nutritional value. Sideritis perfoliata could potentially be useful to reduce the appearance of wrinkles and for the treatment of liver cancer. The moderate antibacterial, antioxidant and elastase activity of the plant can be linked to the traditional use of S. perfoliata for the treatment of wounds and inflammation. View Full-Text
Keywords: Sideritis perfoliata; wrinkles; Cutibacterium acnes; antimycobacterial; melanin inhibition; antioxidant capacity Sideritis perfoliata; wrinkles; Cutibacterium acnes; antimycobacterial; melanin inhibition; antioxidant capacity
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Lall, N.; Chrysargyris, A.; Lambrechts, I.; Fibrich, B.; Blom Van Staden, A.; Twilley, D.; de Canha, M.N.; Oosthuizen, C.B.; Bodiba, D.; Tzortzakis, N. Sideritis Perfoliata (Subsp. Perfoliata) Nutritive Value and Its Potential Medicinal Properties. Antioxidants 2019, 8, 521.

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