Next Article in Journal
Muscle-Specific Modulation of Spinal Reflexes in Lower-Limb Muscles during Action Observation with and without Motor Imagery of Walking
Previous Article in Journal
Behavioral Indices of Neuropsychological Processing Implicated in Moral Domain Reasoning amongst Children and Adolescents
Previous Article in Special Issue
Cystometric Measurements in Rats with an Experimentally Induced Traumatic Brain Injury and Voiding Dysfunction: A Time-Course Study
Open AccessArticle

Cannabis Influences the Putative Cytokines-Related Pathway of Epilepsy among Egyptian Epileptic Patients

1
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, El-Mansoura 35516, Egypt
2
Institute of Forensic and Traffic Medicine, University of Heidelberg, 69115 Heidelberg, Germany
3
Neurology Department, Faculty of Medicine, Mansoura University, El-Mansoura 35516, Egypt
4
Clinical Pathology Department, Faculty of Medicine, Mansoura University, El-Mansoura 35516, Egypt
5
Movement and Training Science Department, Institute of Sports Sciences, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(12), 332; https://doi.org/10.3390/brainsci9120332
Received: 21 October 2019 / Revised: 11 November 2019 / Accepted: 18 November 2019 / Published: 20 November 2019
(This article belongs to the Collection Collection on Clinical Neuroscience)
The study aims to investigate: (1) the prevalence of cannabis among epileptic patients seen at Mansoura University Hospital, (2) serum levels and gene expression of cytokines in epilepsy patients and the controls. and (3) the possibility that cannabis use affects the cytokine levels in epilepsy patients, triggering its future use in treatment. We recruited 440 epilepsy patients and 200 controls matched for age, gender, and ethnicity. Of the epileptic patients, 37.5% demonstrated lifetime cannabis use with a mean duration of 15 ± 73 years. Serum levels of interleukin IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α), were analyzed and gene expression analysis was conducted only for those cytokines that were different between groups in the serum analysis. The “Epilepsy-only” patients had significantly higher serum and mRNA levels of IL-1α, β, IL-2,6,8, and TNF-α compared to the controls and the “Cannabis+Epilepsy” group (p = 0.0001). IL-10 showed significantly lower levels in the “Epilepsy-only” patients compared to the controls and “Cannabis+Epilepsy” (p = 0.0001). Cannabis use is prevalent among epilepsy patients. Epilepsy is characterized by a pro-inflammatory state supported by high serum and gene expression levels. Cannabis users demonstrated significantly lower levels of inflammatory cytokines compared to epilepsy non-cannabis users which might contribute to its use in the treatment of resistant epilepsy. View Full-Text
Keywords: cannabis; purified cannabidiol (CBD); tetrahydrocannabinol (THC); epilepsy; inflammatory cytokines; seizures; treatment-resistant epilepsy; anticonvulsant drugs cannabis; purified cannabidiol (CBD); tetrahydrocannabinol (THC); epilepsy; inflammatory cytokines; seizures; treatment-resistant epilepsy; anticonvulsant drugs
MDPI and ACS Style

Taalab, Y.M.; Fathi Mohammed, W.; Helmy, M.A.; Othman, A.A.; Darwish, M.; Hassan, I.; Abbas, M. Cannabis Influences the Putative Cytokines-Related Pathway of Epilepsy among Egyptian Epileptic Patients. Brain Sci. 2019, 9, 332.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop