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Brain Sciences
Volume 10
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10.3390/brainsci10080487
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Communication

Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults

by
Thiago C. Moulin
1,*,
Federico Ferro
1,
Samuel Berkins
1,
Angela Hoyer
1,
Michael J. Williams
1 and
Helgi B. Schiöth
1,2
1
Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden
2
Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 119146 Moscow, Russia
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(8), 487; https://doi.org/10.3390/brainsci10080487
Submission received: 29 June 2020 / Revised: 13 July 2020 / Accepted: 25 July 2020 / Published: 28 July 2020
(This article belongs to the Special Issue The Role of Dopamine in Neural Circuits)
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Abstract

Imbalances in dopaminergic signaling during development have been indicated as part of the underlying neurobiology of several psychiatric illnesses, including schizophrenia, major depression, bipolar disorder, and food addiction. Yet, how transient manipulation of dopaminergic signaling influences long-lasting behavioral consequences, or if these modifications can induce inheritable traits, it is still not understood. In this study, we used the Drosophila melanogaster model to test if transient pharmacological activation of the dopaminergic system leads to modulations of feeding and locomotion in adult flies. We observed that transient administration of a dopaminergic precursor, levodopa, at 6 h, 3 days or 5 days post-eclosion, induced overfeeding behavior, while we did not find significant effects on locomotion. Moreover, this phenotype was inherited by the offspring of flies treated 6 h or 3 days post-eclosion, but not the offspring of those treated 5 days post-eclosion. These results indicate that transient alterations in dopaminergic signaling can produce behavioral alterations in adults, which can then be carried to descendants. These findings provide novel insights into the conditions in which environmental factors can produce transgenerational eating disorders.
Keywords: L-DOPA; dopamine; feeding; reward; energy intake; development L-DOPA; dopamine; feeding; reward; energy intake; development

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MDPI and ACS Style

Moulin, T.C.; Ferro, F.; Berkins, S.; Hoyer, A.; Williams, M.J.; Schiöth, H.B. Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults. Brain Sci. 2020, 10, 487. https://doi.org/10.3390/brainsci10080487

AMA Style

Moulin TC, Ferro F, Berkins S, Hoyer A, Williams MJ, Schiöth HB. Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults. Brain Sciences. 2020; 10(8):487. https://doi.org/10.3390/brainsci10080487

Chicago/Turabian Style

Moulin, Thiago C., Federico Ferro, Samuel Berkins, Angela Hoyer, Michael J. Williams, and Helgi B. Schiöth. 2020. "Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults" Brain Sciences 10, no. 8: 487. https://doi.org/10.3390/brainsci10080487

APA Style

Moulin, T. C., Ferro, F., Berkins, S., Hoyer, A., Williams, M. J., & Schiöth, H. B. (2020). Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults. Brain Sciences, 10(8), 487. https://doi.org/10.3390/brainsci10080487

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