Search Results (33,965)

Sweden has a very high and variable soil resistivity, making it difficult to ensure a consistently good connection to earth along the track. Booster Transformers (BTs) have been used to ensure that the current returns through the intended path and that stray currents are limited. The ability of BTs to control return currents is limited by their series impedance and by imperfect coupling. In this article, we make a detailed model of the BT system between two feed-in points and evaluate how well the BT system can contain stray currents at harmonic frequencies. The main contribution is that we demonstrate that harmonic currents are significantly less well contained by the BT system, and that the practice of allowing local grid connections to the railway earth system risks creating significant stray currents in the local grid, particularly at harmonic frequencies, but also that electrical safety may be compromised by the transmission of touch voltages to locations with a different soil resistivity than the rail bed. Full article

We conducted this experiment with the aim of investigating the effects of different noise levels from ventilation fans on the growth and slaughter performance, meat quality, blood parameters, and feeding behavior of geese from 21 to 70 days of age. A total of 108 male geese (21-day-old) were randomly assigned to one of three conditions: a control group (no additional fan noise), low-noise treatment (65–75 dB), and high-noise treatment (85–95 dB). Each treatment included six replicates, with six geese per replicate. The results showed that neither ventilation fan noise level significantly affected growth performance, feeding behavior, slaughter performance, or major meat quality traits (p > 0.05). Compared with the control group, noise exposure significantly reduced circulating adrenocorticotropic hormone and corticosterone concentrations (p < 0.05), and the low-noise group exhibited significantly reduced cortisol concentrations (p < 0.05), while the high-noise group had increased cortisol concentrations. Under noise exposure conditions, no statistically significant effects were observed on superoxide dismutase, total antioxidant capacity, malondialdehyde concentration, catalase, and glutathione peroxidase activities compared with the control group (p > 0.05). Overall, prolonged noise stimulation (65–75 dB and 85–95 dB) alleviated stress responses in commercial geese aged 21–70 days, without negatively affecting their growth performance, slaughter performance, meat quality, or feeding behavior. Full article

Background: Ankyloglossia is a congenital anomaly characterized by restricted tongue mobility due to a short, thick, or tight lingual frenulum. Methods: This narrative review synthesizes current concepts on etiology, clinical presentation, diagnostic approaches, functional implications, and management for ankyloglossia in newborns. Results: Ankyloglossia can compromise breastfeeding dynamics, manifesting as suboptimal latch, maternal nipple pain, and inefficient milk transfer, and may influence orofacial function if unrecognized. Because anatomical appearance alone does not reliably predict function, evaluation should prioritize structured functional assessments over purely morphological descriptors. Management should be individualized and stepwise, beginning with lactation support and positioning strategies, and progressing to frenotomy when clear functional limitation persists. In appropriately selected cases, timely intervention can improve feeding efficiency and caregiver comfort while minimizing disruptions to early bonding and nutrition. Post-procedure follow-up is important to confirm functional gains and address residual feeding mechanics. Conclusions: A coordinated, multidisciplinary approach aligns diagnosis and treatment with the infant’s functional needs and family goals, promoting safe, effective, and patient-centered care. Full article

The primary goal of manufacturing technologies in the metalworking industry is to provide products with specified quality characteristics, while maximizing time and cost efficiency. The total manufacturing cost in turning depends on a number of factors. The analysis of their effects and the estimation of the total manufacturing cost are of practical importance in process planning. Therefore, in the present study, the relationship between four inputs (depth of cut, feed rate, cutting speed and volume of material to be removed) and the total manufacturing cost in medium turning of C45E steel was modeled by using an artificial neural network (ANN). The developed ANN model was used for the analysis of the main and interaction effects of the aforementioned inputs on the total manufacturing cost. Verification of the observed effects was also carried out by applying the connection weight approach. The total manufacturing cost was mostly affected by depth of cut, while the effect of cutting speed was least pronounced. In addition, the results also revealed the presence of two-way interactions associated with cutting speed. For the given case study (with defined volume of material to be removed and specified machine tool), an optimized cutting regime was determined by developing and solving a single-objective turning optimization problem with three constraints related to chip slenderness, cutting power and depth of cut. Cutting force, needed for the estimation of cutting power, was estimated by using the dimensional analysis-based prediction model. Full article

We developed an automated folding device for soft plastic bags to replace manual folding. The device employs a flat folding plane, combined with feeding positioning and edge-guided pre-crease. After computing the required torque for every folding step, the actuators are selected. This device increases production output and reduces labor costs. Under typical operating conditions, the production of folded bags has increased to 90 bags per hour, three times that of manual folding, while controlling the crease position deviation within 2.0 mm. With one automated folding device, instead of one laborer, the yield rate was raised to 98%, the production was 187,200 bags per year, and the annual savings were estimated as NT$240,000. Full article

This study investigates the factors affecting surface integrity during the machining of near-β Ti-5553, a critical material in the aerospace and defense industries. Considering this alloy as a difficult-to-machine material, the turning process was examined by analyzing the effects of cutting speed, feed rate, and cooling strategy (dry, conventional, and 30 MPa/High-Pressure cooling) on cutting force, temperature, surface roughness, and residual stress. The primary novelty of this research lies in its integrated approach: rather than evaluating surface integrity metrics in isolation, it simultaneously models interrelated responses to residual stress, cutting temperature, cutting force, and surface roughness under high-pressure coolant (HPC) conditions. Furthermore, it introduces a robust machine learning framework that uniquely applies data augmentation (Gaussian jittering and interpolation) to overcome the conventional constraints of limited experimental machining data, providing a highly accurate predictive tool. The experimental data were expanded using data augmentation methods (Gaussian jittering and interpolation) and modeled using five different machine learning algorithms (Extra Trees, Random Forest, Gradient Boosting, KNN, and AdaBoost). The results revealed that cooling pressure plays a dominant role, particularly in residual stress (importance score: 0.926) and cutting temperature (0.657). It was observed that high-pressure cooling (HPC) reduces thermal gradients, thereby lowering tensile stresses and improving surface integrity. When algorithm performances were compared, the Extra Trees and Random Forest models achieved the most accurate predictions after hyperparameter optimization. Specifically, the optimized Extra Trees regressor demonstrated exceptional predictive capability for residual stress, achieving an accuracy of 98.47%, a remarkably high coefficient of determination (R² = 0.9997), and a minimal Mean Squared Error (MSE = 6.8289). These quantitative results confirm that the proposed machine learning framework provides a highly reliable and precise tool for controlling surface quality in HPC- assisted machining. Full article

This study investigated the effects of dietary lysophospholipids on growth performance, hepatic lipid metabolism, intestinal health, and dietary lipid levels of largemouth bass. The 56-day experiment included five groups: CON (0% lysophospholipids), LL50 (0.05% lysophospholipids), LP50 (0.05% lysophospholipids—0.5% oil), LP100 (0.1% lysophospholipids—1.0% oil), and LP200 (0.1% lysophospholipids—2.0% oil), with 3 replicates (30 fish/replicate) per group. The results showed that compared with the CON group, dietary supplementation of 0.05% lysophospholipid had no significant effect on the growth performance of largemouth bass, but increased the crude protein content and decreased the crude lipid content in the whole body. An amount of 0.05% lysophospholipid improved hepatic lipid utilization efficiency. Specifically, this supplementation level promoted serum lipid transport (increased serum HDL-C content and decreased triglyceride and LDL-C contents), and enhanced hepatic lipid metabolism by regulating the expression of lipid metabolism-related genes (fas, hsl, and acc) and the levels of lipid metabolites (phosphatidylcholine and fatty acids), thereby reducing hepatic triglyceride content. In addition, 0.05% lysophospholipid improved intestinal health by increasing lipase activity and intestinal villus height, up-regulating the expression of the anti-inflammatory gene (tgf-β1) and tight junction protein genes (claudin-1, claudin-4, and zo-1), and down-regulating the expression of the pro-inflammatory gene (tnf-α). In terms of dietary lipid reduction, supplementation with 0.1% lysophospholipid allowed a 1% reduction in dietary lipid level without affecting the growth performance of largemouth bass, whereas at the same level of lysophospholipid supplementation, a 2% reduction in dietary lipid level resulted in decreased growth performance of largemouth bass. These findings provide theoretical support for the practical application of lysophospholipids, and demonstrate that reducing dietary lipid inclusion by adding lysophospholipids helps to reduce feed costs and improve aquaculture economic benefits. Full article

Fully maintenance-free smart collars for range cattle, sheep and deer must survive years of uncontrolled grazing under highly variable shade and motion conditions. This paper presents an ultra-low-power buck converter governed by a fast integral terminal sliding mode controller (FITSMC) with a fixed-time observer. A new reaching law retains the initial sliding manifold and a negative-power term maintains the constant switching gain to preserve robustness near the surface while attenuating chattering without widening the bandwidth. The fixed-time observer estimates the irradiance and load changes and provides a feed-forward correction, tightening the output regulation regardless of initial conditions. Load step tests with moderate resistance swings showed the proposed method recovers noticeably faster and exhibits slightly lower overshoot than a recent method based on a two-phase power reaching law, while visible inductor current spikes are also suppressed. Simulations under daily grazing profiles confirmed tight output regulation adequate for microwatt data logging and periodic long-range (LoRa) bursts. The sleep mode quiescent current remained in the 9 microamps range, eliminating the need for manual recharge across multi-season field deployments. By integrating robust power electronics with collar-grade solar harvesting, the circuit offers a truly maintenance-free energy path for untethered livestock wearables and supports sustainable precision agriculture. Full article

Bacillus subtilis is aerobic or facultatively anaerobic. After entering the gastrointestinal tract, its spores germinate and colonize the gut, inhibiting the growth of harmful aerobic bacteria (Escherichia coli, Streptococcus, Staphylococcus aureus). However, it remains unclear whether B. subtilis can inhibit Clostridium perfringens type A infection. In this study, B. subtilis PB6 was added to the diets of pregnant sows infected with Clostridium perfringens type A, which significantly improved the reproductive performance and reduced the incidence of bloat in sows and diarrhea in neonatal piglets. The treatment significantly increased the abundance of intestinal probiotics (B. subtilis, Lactobacillus, Limosilactobacillus reuteri, Lactobacillus johnsonii, Muribaculaceae, Lactobacillus amylovorus, and Lactobacillus reuteri) in sows and decreased the relative abundance of Clostridium perfringens type A after feeding B. subtilis administration. These probiotics can repair the intestinal tissue and improve intestinal histomorphology, and enhance the expression of MUC2 and sIgA in sows, thereby further strengthening the mucosal immune function. B. subtilis can also reduce the levels of inflammatory factors (CRP, IL-1β, and IFN-γ) and attenuate the inflammatory response in sows and neonatal piglets. Taken together, our results suggest that dietary supplementation with B. subtilis PB6 could reduce bloat in sows and diarrhea in piglets while improving intestinal barrier function and microbial balance in sows. Full article

This study aimed to investigate the effects of feeding high-moisture corn (HMC) on weight performance, serum immune and antioxidant indices, rumen fermentation, microbial community, and metabolomics in Kazakh rams. A total of 32 healthy Kazakh rams were randomly divided into a control group (CT, diet with only ordinary crushed corn) and an experimental group (GS, diet with 50% ordinary crushed corn + 50% HMC), following a 7-day adaptation period and a 120-day trial period. Results showed that the F/G was significantly lower in the GS group than in the CT group (p < 0.05). FBW, net weight gain and ADG increased by 4.58%, 8.69%, and 8.70%, respectively, while ADFI decreased by 7.04% (p > 0.05). Regarding serum immune indices, IgA in the GS group was significantly higher at 40 d (p < 0.01), and IgM was significantly higher at 40, 80, and 120 d (p < 0.05). For antioxidant indices, the SOD activity in the GS group was significantly higher than that in the CT group at 120 d (p < 0.01). The CAT activity in the GS group was significantly higher at 40, 80, and 120 d (p < 0.01). Among rumen fermentation parameters, the concentration of butyric acid in the GS group was significantly lower than in the CT group (p < 0.01). Microbial diversity analysis indicated no significant differences in Alpha- and Beta-diversity of rumen microorganisms between the two groups. However, the relative abundance of Firmicutes_A at the phylum level was significantly higher in the GS group (p < 0.05), and the abundance of Cryptobacteroides was significantly higher than in the CT group (p < 0.01). Rumen metabolomic analysis identified a total of 1357 differential metabolites, among which 1130 showed significant differences, with 459 upregulated and 671 downregulated. These were mainly enriched in pathways such as Glutathione metabolism, Beta-alanine metabolism, Sphingolipid metabolism, and lysine degradation. In conclusion, feeding HMC can improve feed conversion efficiency and weight performance in Kazakh rams, regulate the structure of dominant rumen microorganisms, and enhance immune and antioxidant capacities. Full article

Deoxynivalenol (DON), a Fusarium-derived mycotoxin widely found in grain-based feed, has become a major global environmental contaminant. Reproductive toxicity is one of its most important toxic effects, yet systematic investigations covering both male and female reproductive injury remain limited. This study aimed to establish a combined strategy of network toxicology, molecular docking, molecular dynamics simulation, and single-cell RNA sequencing to evaluate the reproductive toxicity of DON. AKT1, EGFR, PIK3CA, PIK3R1, and SRC were identified as key targets involved in DON-induced reproductive injury. For testicular injury, the prolactin, Ras, HIF-1, and AGE-RAGE signaling pathways were closely associated with DON toxicity. For ovarian injury, the PI3K-Akt, HIF-1, prolactin, insulin, and AGE-RAGE signaling pathways were strongly implicated. Molecular docking demonstrated favorable binding affinities between DON and the hub targets, while molecular dynamics simulation further confirmed the stability of the DON–PIK3CA complex. Single-cell RNA sequencing analysis revealed that these five hub genes were highly expressed in both testicular (SRA667709:SRS3065430) and ovarian (SRA638923:SRS2797100) tissues. These findings deepen current understanding of DON-induced reproductive toxicity, provide new insights into the effects of environmental toxins on reproductive health, and offer a theoretical basis for future studies integrating DON exposure with in vivo validation of core targets and signaling pathways. Full article

Shellfish are one of the important aquatic products in coastal areas. Due to their feeding mechanism, viruses can accumulate in their tissues during the feeding process. Most of the current research on HEV in shellfish is limited to the sampling of the surface layer to detect its prevalence, and traditional quantitative risk assessment methods face challenges in assessing the potential risks associated with consumption. Using the R language, we combined 2011–2024 literature detection data with experimental results to simulate infection risk for Chinese urban and rural residents under cooked and raw-consumption scenarios. Single-exposure infection probabilities were similar, but annual risks were comparable across groups. For urban residents, the 95% CrI of annual risk was 3.83 × 10⁻⁵ (2.5 × 10⁻⁶–3.56 × 10⁻⁴) (raw) and 1.2 × 10⁻⁸ (3.8 × 10⁻¹⁰–4.3 × 10⁻⁷) (cooked); for rural residents, the confidence interval was 2.69 × 10⁻⁵ (1.8 × 10⁻⁶–2.50 × 10⁻⁴) (raw) and 8.4 × 10⁻⁹ (2.5 × 10⁻¹⁰–3.0 × 10⁻⁷) (cooked). By assessing the prevalence of HEV in shellfish and the probability of infection after consumption, the safety awareness of the Chinese population regarding shellfish consumption can be strengthened. Also, suggestions can be derived from HEV prevalence data in various countries, to improve the breeding environment and reduce relevant prevalence and risks. Full article

A 6-week feeding trial evaluated composite protein mixtures as partial replacements for fish meal (FM) in diets for juvenile yellowtail (Seriola quinqueradiata). Five diets were prepared: a control diet (C) with FM as the main protein source, and four test diets in which 25% and 35% of FM protein were replaced by either a composite mixture of SSM (44% shark by-product meal + 56% surimi by-product mixture; SS25 and SS35) or SMM (58% shark by-product meal + 42% other by-product mixture; SM25 and SM35). Fish (initial mean weight 0.85 g) were stocked at 30 fish per 500-L tank, with three replicate tanks per treatment. Growth performance indicators, including final mean weight, percent weight gain, specific growth rate, daily feeding rate, and survival, did not differ significantly among treatments (p > 0.05). Feed efficiency was significantly higher in SS25 and SS35 than in the control (p < 0.05), whereas no significant differences were observed among the by-product-based diets. Whole-body proximate composition was unaffected, except for crude ash. The levels of key n-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, were significantly lower in SM25 and SM35 than in the control (p < 0.05). These results indicate that up to 35% of FM protein can be replaced with shark by-product-based mixtures without compromising growth in juvenile yellowtail. Full article

Background/Objectives: Nerolidol (NER) is a sesquiterpene alcohol with recognized antimicrobial potential, whose applications as a pure substance are limited by hydrophobicity, instability, and cytotoxicity. Invasomes, i.e., liposomes with terpene ingredients, offer a strategy to improve their delivery; however, the NER loading limits compatible with vesicle integrity are still unclear. Here, Nerolidol-loaded invasomes were produced using a controlled simil-microfluidic coaxial injection process. Methods and Results: As a preliminary step, unloaded liposomes were fabricated to consolidate operating conditions and ensure their reproducible colloidal properties. Thereafter, formulations with progressively decreasing nominal NER loads were investigated to evaluate vesicle size, polydispersity, ζ-potential, encapsulation efficiency, effective loading, and stability. High nominal loads promoted turbidity, size increase (by agglomeration coalescence phenomena), and structural instability, whereas formulations containing approximately 1–2% NER achieved nearly complete encapsulation, Z-average ≈ 300 nm, |ζ| > 30 mV, and satisfactory physical stability. Antimicrobial and cytotoxic profiles of representative formulations, previously evaluated in an independent study are here reported only to contextualize the practical relevance of the optimized systems, while the present work primarily focuses on process–formulation aspects and loading/stability limitations. Conclusions: Overall, the present work identifies a realistic loading window for Nerolidol invasomes and highlights the suitability of the simil-microfluidic approach to obtain scalable, well-controlled formulations, providing a rational basis for their future biological assessment. Nerolidol invasome systems indeed can be considered a promising, versatile platform for antimicrobial applications, including prospective use in animal feed. Full article

Nanofiltration (NF) is increasingly applied for advanced drinking water treatment, but achieving stable operation at high recovery rates remains challenging for surface waters with high scaling potential. This pilot study investigated the performance and optimization of a three-stage NF270 system (4:2:1 tapered array) for treating coagulated surface water in northern Jiangsu, China, aiming to identify sustainable operating conditions for high-recovery applications. The NF system was operated at recoveries of 80–90% with a feed flux of 20–23 LMH, and the effects of forward flushing frequency, acid dosing location, and concentrate recirculation on fouling behavior were evaluated. The NF270 membrane achieved consistent removal of organic matter (effluent chemical oxygen demand (COD_Mn) < 0.5 mg/L), hardness (40–60% rejection), and alkalinity (~20% rejection), meeting Jiangsu Province drinking water standards. However, operation at 90% recovery resulted in rapid third-stage fouling, with permeate flow declining by >60% within 2.5 h. Osmotic pressure analysis (local concentrate osmotic pressure: 3.8–4.2 bar; net driving pressure: 0.8–2.2 bar) confirmed physical scaling rather than hydraulic limitation as the dominant mechanism. Stage-wise concentration factor calculations (CF₁ = 1.6, CF₂ = 2.9, CF₃ = 4.4) revealed local Langelier Saturation Index (LSI) values of 1.8–2.2 in the third stage, identifying CaCO₃ supersaturation as the primary scaling cause. Reducing recovery to 85% and flux to 20 LMH with 2 h forward flushing extended stable operation. Acid addition effectively mitigated scaling, but dosing location was critical: first-stage addition (pH 8.1 → 7.6) reduced third-stage LSI to 0.7–0.9 and stabilized performance, whereas third-stage addition (pH 8.0 → 7.3) inadvertently promoted Al(OH)₃ precipitation from residual coagulant (feed Al: 0.07–0.11 mg/L). Concentrate recirculation (90% ratio) did not alleviate fouling. These findings demonstrate that for aluminum-rich coagulated surface waters, optimizing recovery, flushing frequency, and acid dosing location is essential for sustainable NF operation, and provide engineering guidance for full-scale applications. Full article