Next Article in Journal
Peridynamic Modeling of Mode-I Delamination Growth in Double Cantilever Composite Beam Test: A Two-Dimensional Modeling Using Revised Energy-Based Failure Criteria
Next Article in Special Issue
Acceleration of OCT Signal Processing with Lookup Table Method for Logarithmic Transformation
Previous Article in Journal
Investigating the Effect of Cutting Parameters of Ti–6Al–4V on Surface Roughness Based on a SPH Cutting Model
Previous Article in Special Issue
In Vivo Rat Brain Imaging through Full-Field Optical Coherence Microscopy Using an Ultrathin Short Multimode Fiber Probe
Open AccessArticle

Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome

1
Polo Cardio-Toraco-Vascolare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy
2
Istituto di Medicina Nucleare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy
3
Istituto di Radiologia, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, Italy
4
CLI Foundation, 00182 Rome, Italy
5
GVM Care & Research, Ettore Sansavini Health Science Foundation, 48033 Cotignola, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(4), 657; https://doi.org/10.3390/app9040657
Received: 21 November 2018 / Revised: 29 January 2019 / Accepted: 4 February 2019 / Published: 15 February 2019
(This article belongs to the Special Issue Optical Coherence Tomography and its Applications)
Objectives: High cystatin C(CysC) levels are associated with impaired cardiovascular outcome. Whether CysC levels are independently related to the atherosclerosis burden is still controversial. Methods: We enrolled 31 non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention. Patients were divided into 2 groups on the basis of median value of serum CysC. Using the high CysC group as a dependent variable, univariable and multivariable analyses were used to evaluate the association between CysC and three different features of atherosclerosis: 1) coronary plaque vulnerability as assessed by optical coherence tomography (OCT), 2) coronary artery calcium (CAC) by means of computed tomography scan, and 3) aortic wall metabolic activity, as assessed using 18F-Fluorodeoxyglucose-positron emission tomography (18F-FDG-PET). Results: After univariable and multivariable analyses, 18F-FDG uptake in the descending aorta (DA) was independently associated with a low level of CysC [(Odds Ratio = 0.02; 95%CI 0.0004–0.89; p = 0.044; 18F-FDG uptake measured as averaged maximum target to blood ratio); (Odds Ratio = 0.89; 95%CI 0.82–0.98, p = 0.025; 18F-FDG uptake measured as number of active slices)]. No trend was found for the association between CysC and characteristics of OCT-assessed coronary plaque vulnerability or CAC score. Conclusions: In patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), 18F-FDG uptake in the DA was associated with a low level of serum CysC. There was no relation between CysC levels and OCT-assessed coronary plaque vulnerability or CAC score. These findings suggest that high levels of CysC may not be considered as independent markers of atherosclerosis. View Full-Text
Keywords: cystatin C; 18F-fluorodeoxyglucose-positron emission tomography; frequency domain-optical coherence tomography; coronary artery calcium score; non-ST-segment elevation acute coronary syndrome cystatin C; 18F-fluorodeoxyglucose-positron emission tomography; frequency domain-optical coherence tomography; coronary artery calcium score; non-ST-segment elevation acute coronary syndrome
Show Figures

Figure 1

MDPI and ACS Style

Taglieri, N.; Nanni, C.; Ghetti, G.; Bonfiglioli, R.; Saia, F.; Buia, F.; Lima, G.M.; Marco, V.; Bruno, A.G.; Prati, F.; Fanti, S.; Rapezzi, C. Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome. Appl. Sci. 2019, 9, 657.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop