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Open AccessArticle

Autologous Tooth Graft after Endodontical Treated Used for Socket Preservation: A Multicenter Clinical Study

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University of Bari Aldo Moro, 70121 Bari, Italy
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Private Practice, 20100 Milan, Italy
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College of Medicine and Dentistry Birmingham, University of Birmingham, Birmingham B15 2TT, UK
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Private Practice, 73100 Lecce, Italy
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Private practice, Singapore 238863
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University of Naples Federico II, 80100 Naples, Italy
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Visiting Professor University of Genoa, 16126 Genova, Italy
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Private Practice, 10121 Turin, Italy
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Private Practice, 50002 Hradec Kralove, Czech Republic
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Private Practice, 34121 Trieste, Italy
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Olomouc University, 77147 Olomouc, Czech Republic
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School of Medicine, University of Bari, 70121 Bari, Italy
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School of Dentistry, University of Foggia, 71122 Foggia, Italy
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Private Practice - Biomaterial Clinical and Histological Research Association
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Clinical and Experimental Medicine Dept. School of Dentistry University of Foggia, 71122 Foggia, Italy
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Authors to whom correspondence should be addressed.
Appl. Sci. 2019, 9(24), 5396; https://doi.org/10.3390/app9245396
Received: 22 October 2019 / Revised: 13 November 2019 / Accepted: 29 November 2019 / Published: 10 December 2019
(This article belongs to the Special Issue Bio-Inspired Biodegradable Scaffold Constructs for Bone Tissue Repair)
The aim of the study was to evaluate the tooth extracted use as autologous tooth graft after endodontic root canal therapies used for socket preservation. To this purpose, the Tooth Transformer shredding and decontamination machine has been used. The graft obtained in this way, was inserted at the time of the extraction or at a second surgery altogether with the chosen regenerative therapy. This clinical trial enrolled patients with post-estractive defects requiring the restoration bone dimension and shape in the maxillary and mandibular zone. In addition, 98 patients with 119 extraction sockets were enrolled across 10 standardized centers. An innovative preparation method, using the dedicated automated device Tooth Transformer, able to transform autologous teeth in suitable grafting material, has been used. The extracted tooth was cleaned and treated using a Tooth Transformer and made a socket preservation. Thirteen Biopsies were realized to analyze the histologic outcomes at the average time of four months to demonstrate that the autologous tooth graft made from root after endodontic therapy should be used in human bone regeneration as graft for dental implant placement. View Full-Text
Keywords: teeth; root canal; tooth graft; regeneration teeth; root canal; tooth graft; regeneration
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MDPI and ACS Style

Minetti, E.; Palermo, A.; Ferrante, F.; Schmitz, J.H.; Lung Ho, H.K.; Dih Hann, S.N.; Giacometti, E.; Gambardella, U.; Contessi, M.; Celko, M.; Ballini, A.; Mortellaro, C.; Trisi, P.; Mastrangelo, F. Autologous Tooth Graft after Endodontical Treated Used for Socket Preservation: A Multicenter Clinical Study. Appl. Sci. 2019, 9, 5396.

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