New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study
Abstract
1. Introduction
2. Aim
3. Materials and Methods
4. Results
5. Discussion
Author Contributions
Funding
Conflicts of Interest
References
- Papapanou, P.N.; Sanz, M.; Buduneli, N.; Dietrich, T.; Feres, M.; Fine, D.H.; Flemmig, T.F.; Garcia, R.; Giannobile, W.V.; Graziani, F.; et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol. 2018, 89, S173–S182. [Google Scholar] [CrossRef] [PubMed]
- Shaddox, L.M.; Mullersman, A.F.; Huang, H.; Wallet, S.M.; Langaee, T.; Aukhil, I. Epigenetic regulation of inflammation in localized aggressive periodontitis. Clin Epigenetics 2017, 9, 94. [Google Scholar] [CrossRef] [PubMed]
- Adamczyk, M.; Orzechowska, A.; Napora, M.; Wyszyńska, M.; Górska, R. Częstość występowania chorób przyzębia u mieszkańców Warszawy w wieku 35–44 lat na podstawie wskaźnika CPITN Borgis. Nowa Stomatol. 2013, 2, 93–97. [Google Scholar]
- Górska, R.; Pietruska, M.; Dembowska, E.; Wysokińska-Miszczuk, M.; Włosowicz, M.; Konopka, T. Częstość występowania chorób przyzębia u osób w wieku 35–44 lat w populacji dużych aglomeracji miejskich. Przegl. Epidemiol. 2015, 69, 537–542, 643–647. [Google Scholar]
- Konopka, T.; Dembowska, E.; Pietruska, M.; Dymalski, P.; Górska, R. Periodontal status and selected parameters of oral condition of Poles aged 65 to 74 years. Przegl. Epidemiol. 2015, 69, 537–542. [Google Scholar]
- Głowacka, B.; Konopka, T. Needs for gerodontological treatment in the elderly living in Lower Silesia. Dent. Med. Probl. 2019, 56, 89–96. [Google Scholar] [CrossRef]
- Pei Shian, T.; Pulikkotil, S. Comparison and agreement among variouscase definitions of periodontitis: A secondary data analysis. J. Periodontol. Implant Dent. 2014, 6, 40–46. [Google Scholar] [CrossRef]
- Goodson, J.M.; Haffaje, A.; Socransky, S. Periodontal therapy by local delivery of tetracycline. J. Clin. Periodontol. 1979, 6, 83–92. [Google Scholar] [CrossRef]
- Kinane, D.F.; Stathopoulou, P.G.; Papapanou, P.N. Periodontal diseases. Nat. Rev. Dis. Primers 2017, 3, 17038. [Google Scholar] [CrossRef]
- Lauenstein, M.; Kaufmann, M.; Persson, G.R. Clinical and microbiological results following nonsurgical periodontal therapy with or without local administration of piperacillin/tazobactam. Clin. Oral Investig. 2013, 17, 1645–1660. [Google Scholar] [CrossRef][Green Version]
- Jervøe-Storm, P.M.; Al Ahdab, H.; Semaan, E.; Fimmers, R.; Jepsen, S. Microbiological outcomes of quadrant versus full-mouth root planning as monitored by real-time PCR. J. Clin. Periodontol. 2007, 34, 156–163. [Google Scholar] [CrossRef] [PubMed]
- Knöfler, G.U.; Purschwitz, R.E.; Jentsch, H.F. Clinical evaluation of partial- and full-mouth scaling in the treatment of chronic periodontitis. J. Periodontol. 2007, 78, 2135–2142. [Google Scholar] [CrossRef]
- Roman-Torres, C.V.G.; Bryington, M.S.; Kussaba, S.T.; Pimentel, A.C.; Jimbo, R.; Cortelli, J.R.; Romito, G.A. Comparison Of Full-Mouth Scaling and Quadrant-Wise Scaling in the Treatment of Adult Chronic Periodontitis. Braz. Dent. J. 2018, 29, 296–300. [Google Scholar] [CrossRef] [PubMed]
- Al Hulami, H.; Babay, N.; Awartani, F.; Anil, S. The effect of locally delivered doxycycline as an adjunctive therapy to scaling and root planing in smokers. Saudi Dent. J. 2011, 23, 143–148. [Google Scholar] [CrossRef] [PubMed]
- Szulc, M.; Zakrzewska, A.; Zborowski, J. Local drug delivery in periodontitis treatment: A review of contemporary literature. Dent. Med. Probl. 2018, 55, 333–342. [Google Scholar] [CrossRef]
- Ahamed, S.; Jalaluddin, M.; Khalid, I.; Moon, N.; Shafi, T.K.; Ali, F.M. The use of controlled release locally delivered 10% doxycycline hyclate gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis: Clinical and microbiological results. J. Contemp. Dent. Pract. 2013, 14, 1080–1086. [Google Scholar]
- Sandhya, Y.P.; Prabhuji, M.L.; Chandra, R.V. Comparative evaluation of the efficacy of 10% doxycycline hyclate in the periodontal treatment of smokers—A clinical and microbiological study. Oral Health Prev. Dent. 2011, 9, 59–65. [Google Scholar]
- Bogren, A.; Teles, R.P.; Torresyap, G.; Haffajee, A.D.; Socransky, S.S.; Wennström, J.L. Locally delivered doxycycline during supportive periodontal therapy: A 3-year study. J. Periodontol. 2008, 79, 827–835. [Google Scholar] [CrossRef]
- Tsalikis, L.; Sakellari, D.; Dagalis, P.; Boura, P.; Konstantinidis, A. Effects of doxycycline on clinical, microbiological and immunological parameters in well-controlled diabetes type-2 patients with periodontal disease: A randomized, controlled clinical trial. J. Clin. Periodontol. 2014, 41, 972–980. [Google Scholar] [CrossRef]
- Mombelli, A.; Schmid, B.; Rutar, A.; Lang, N.P. Local antibiotic therapy guided by microbiological diagnosis. J. Clin. Periodontol. 2002, 29, 743–749. [Google Scholar] [CrossRef]
- Mombelli, A. Microbial colonization of the periodontal pocket and its significance for periodontal therapy. Periodontology 2000 2018, 76, 85–96. [Google Scholar] [CrossRef] [PubMed]
- John, M.T.; Michalowicz, B.S.; Kotsakis, G.A.; Chu, H. Network meta-analysis of studies included in the Clinical Practice Guideline on the nonsurgical treatment of chronic periodontitis. J. Clin. Periodontol. 2017, 44, 603–611. [Google Scholar] [CrossRef] [PubMed]
Place of the Test | BoP | PD śr | PD | Mediana PD > 5 mm | Mediana CAL1-2 | Mediana CAL3-4 | Mediana CAL ≥ 5 |
---|---|---|---|---|---|---|---|
Upper Jaw | 63.3 ± 22.3 | 4.23 ± 0.92 | 4.86 ± 1.15 | 10 | 7.5 | 13 | 26 |
30.3 ± 12.1 p < 0.000 | 3.78 ± 0.97 p = 0.049 | 4.31 ± 1.12 p = 0.047 | 5.5 p = 0.59 | 11 p = 0.17 | 7.5 p = 0.44 | 14.5 p = 0.012 | |
Pockets SRP+A | 87.5 ± 20.9 | 5.0 ± 1.04 | CAL śr 3.96 ± 1.36 | ||||
38.3 ± 12.5 p < 0.000 | 4.18 ± 0.92 p = 0.008 | 3.1 ± 2.02 p = 0.053 | |||||
Pockets SRP | 85.8 ± 14.2 | 4.83 ± 1.18 | 3.41 ± 1.63 | ||||
38.3 ± 23.9 p < 0.000 | 4.0 ± 0.99 p = 0.005 | 2.6 ± 1.34 p = 0.037 |
Type of Bacteria | SRP+A Treatment | SRP Treatment | P for Rows |
---|---|---|---|
TBC before after | 455,603,800 ± 774,832,582 225,700,000 ± 160,305,299 T26, p = 0.88 | 138,810,000 ± 184,812,292 400,090,000 ± 710,668,522 T16, p = 0.24 | U = 50 ns U = 50 ns |
P.g. before after | 55,050 ± 105,157 94,000 ± 239,040 T8, p = 0.6 | 54,328 ± 146,867 182,514 ± 365,513 T5, p = 0.25 | U = 43 ns U = 47 ns |
T.d. before after | 4802 ± 5793 36,188 ± 79,754 T3, p = 0.036 | 6456 ± 11,483 35,460 ± 50,421 T9, p = 0.11 | U = 42 ns U = 48.5 ns |
T.f. before after | 11,372 ± 23,587 7996 ± 10,964 T11, p = 0.33 | 40,227 ± 106,011 16,657 ± 29,545 T21, p = 0.86 | U = 49.5 ns U = 47 ns |
A.a before after | Liczba wykryć-3 Liczba wykryć-2 | Liczba wykryć-2 Liczba wykryć-1 | |
F.n. before after | 6800 ± 14,499 466 ± 615 T10, p = 0.26 | 8257 ± 18,822 716 ± 1320 T6, p = 0.051 | U = 35 ns U = 43 ns |
P.i. before after | 43,404 ± 106,163 199,610 ± 497,956 T8, p = 0.6 | 61,153 ± 144,493 23,765 ± 69,086 T5, p = 0.25 | U = 46 ns U = 40 ns |
P.m. before after | 2877 ± 2644 631 ± 767 T3, p = 0.036 | 5914 ± 11,514 589 ± 616 T6, p = 0.051 | U = 49.5 ns U = 48.5 ns |
E.n. before after | Liczba wykryć-1 Liczba wykryć-1 | Liczba wykryć-1 Liczba wykryć-2 | |
C.g. before after | 14,636 ± 37,211 5439 ± 4962 T25, p = 0.8 | 5878 ± 6165 2050 ± 1796 T8, p = 0.086 | U = 41.5 ns U = 22.5 |
Type of Bacteria | Stage II and III vs. IV | p | Grade B vs. C | p |
---|---|---|---|---|
TBC before after | 404,295,571 ± 660,136,448 vs. 473,333,333 ± 493,301,180 386,071,429 ± 595,735,933 vs. 142,150,000 ± 114,175,369 | 0.23 0.16 | 410,078,571 ± 656,851,542 vs. 33,839,667 ± 42,535,311 369,428,571 ± 602,988,291 vs. 180,983,333 ± 102,863,996 | 0.048 0.74 |
P.g. before after | 64,141 ± 145,840 vs. 32,633 ± 50,957 73,439 ± 230,011 vs. 289,500 ± 417,614 | 0.59 0.59 | 68,641 ± 144,276 vs. 22,133 ± 52,856 79,653 ± 229,047 vs. 275,000 ± 427,446 | 0.3 0.71 |
T.d. before after | 5731 ± 9219 vs. 5392 ± 8920 40,956 ± 74,652 vs. 23,850 ± 35,928 | 0.9 0.48 | 7438 ± 10,099 vs. 1408 ± 2223 41,263 ± 74,510 vs. 23,133 ± 36,272 | 0.3 0.54 |
T.f. before after | 32,595 ± 90,773 vs. 9943 ± 14,466 11,238 ± 21,684 vs. 14,867 ± 25,083 | 0.62 0.77 | 34,431 ± 90,504 vs. 5660 ± 8455 11,224 ± 21,730 vs.15,133 ± 24,856 | 0.71 0.97 |
A.a before after | Liczba wykryć-3 vs. 2 Liczba wykryć-2 vs. 1 | Liczba wykryć-3 vs. 2 Liczba wykryć-2 vs. 1 | ||
F.n. before after | 9221 ± 19,245 vs. 3578 ± 5346 565 ± 856 vs. 652 ± 1405 | 0.59 0.65 | 9264 ± 19,221 vs. 3478 ± 5442 457 ± 873 vs. 903 ± 1318 | 0.97 0.26 |
P.i. before after | 40,398 ± 92,291 vs. 80,000 ± 186,333 148,125 ± 424,800 vs. 26,667 ± 65,320 | 0.53 0.2 | 66,669 ± 14,447 vs. 18,700 ± 44,736 158,075 ± 423,223 vs. 3450 ± 7209 | 0.34 0.33 |
P.m. before after | 2948 ± 2751 vs. 7773 ± 14,874 695 ± 676 vs. 412 ± 702 | 0.77 0.2 | 5547 ± 9698 vs. 1708 ± 1891 544 ± 564 vs. 765 ± 937 | 0.36 0.77 |
E.n. before after | Liczba wykryć-2 vs. 0 Liczba wykryć-3 vs. 0 | Liczba wykryć-2 vs. 0 Liczba wykryć-3 vs. 0 | ||
C.g. before after | 12,261 ± 31,319 vs. 5580 ± 7049 3264 ± 2426 vs. 4867 ± 6646 | 0.45 0.87 | 13,679 ± 31,124 vs. 2272 ± 3107 3336 ± 2366 vs. 4698 ± 6746 | 0.09 0.65 |
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Sender-Janeczek, A.; Zborowski, J.; Szulc, M.; Konopka, T. New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study. Appl. Sci. 2019, 9, 5077. https://doi.org/10.3390/app9235077
Sender-Janeczek A, Zborowski J, Szulc M, Konopka T. New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study. Applied Sciences. 2019; 9(23):5077. https://doi.org/10.3390/app9235077
Chicago/Turabian StyleSender-Janeczek, Aleksandra, Jacek Zborowski, Małgorzata Szulc, and Tomasz Konopka. 2019. "New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study" Applied Sciences 9, no. 23: 5077. https://doi.org/10.3390/app9235077
APA StyleSender-Janeczek, A., Zborowski, J., Szulc, M., & Konopka, T. (2019). New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study. Applied Sciences, 9(23), 5077. https://doi.org/10.3390/app9235077