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Open AccessReview

Effect of Tinospora cordifolia-Derived Phytocomponents on Cancer: A Systematic Review

1
Department of Oral Pathology and Microbiology, Maratha Mandal’s NATHAJIRAO G. HALGEKAR Institute of Dental Sciences and Research Centre, Belgaum 590010, India
2
Department of Maxillofacial Surgery, College of Dental Sciences, Rajiv Gandhi University of Health Sciences, Davanagere 577004, India
3
Department of Dental Sciences, Oral Pathology Division, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia
4
Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia
5
Department of Dental Health, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia
6
Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India
7
Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(23), 5147; https://doi.org/10.3390/app9235147
Received: 28 October 2019 / Revised: 22 November 2019 / Accepted: 26 November 2019 / Published: 28 November 2019
The major cancer therapeutic modalities include surgery, chemotherapy and radiotherapy. Although these treatment regimens have played a significant role in effectively inhibiting cancer, their associated morbidity reduces the overall quality of life. Thus, researchers are striving to identify any alternate therapeutic approach capable of inhibiting cancer without eliciting the added morbidity. Among the alternate cancer therapeutics being researched, much importance is being given to the use of plants due to the presence of a wide variety of anti-carcinogenic compounds. Tinospora cordifolia (Tc) is one such plant and has shown to exhibit anti-carcinogenic properties. The present review aimed to systematically analyze published data on the effect of Tinospora cordifolia-derived phytocomponents on cancer. PubMed, Scopus, Web of Science, Embase and Cochrane library were searched using the keywords Tinospora cordifolia; anticancer; phytocomponents until March 20, 2019. In vivo and in vitro original studies in the English language were included. Of the 342 articles identified, only 25 articles met the selection criteria and were included in the review. Significant anti-carcinogenic properties were exhibited by Tinospora cordifolia-derived phytocompounds including palmative, berberine, new clerodane furanoditerene glycoside, arabinogalactan, phenolic compounds and epoxy cleodane diterpene. No significant side effects have been elicited with its use. Based on the data from the included studies, Tinospora cordifolia could be a natural therapeutic agent for cancer, provided its anti-carcinogenic properties can be elicited consistently at a large scale in clinical trials. View Full-Text
Keywords: cancer; phytocomponents; Tiospora cardifolia cancer; phytocomponents; Tiospora cardifolia
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MDPI and ACS Style

Deepa, B.; Babaji, H.V.; Hosmani, J.V.; Alamir, A.W.H.; Mushtaq, S.; Raj, A.T.; Patil, S. Effect of Tinospora cordifolia-Derived Phytocomponents on Cancer: A Systematic Review. Appl. Sci. 2019, 9, 5147. https://doi.org/10.3390/app9235147

AMA Style

Deepa B, Babaji HV, Hosmani JV, Alamir AWH, Mushtaq S, Raj AT, Patil S. Effect of Tinospora cordifolia-Derived Phytocomponents on Cancer: A Systematic Review. Applied Sciences. 2019; 9(23):5147. https://doi.org/10.3390/app9235147

Chicago/Turabian Style

Deepa, Babji; Babaji, Harsha V.; Hosmani, Jagadish V.; Alamir, Abdul W.H.; Mushtaq, Shazia; Raj, A. T.; Patil, Shankargouda. 2019. "Effect of Tinospora cordifolia-Derived Phytocomponents on Cancer: A Systematic Review" Appl. Sci. 9, no. 23: 5147. https://doi.org/10.3390/app9235147

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