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Open AccessReview

Acellular Small-Diameter Tissue-Engineered Vascular Grafts

by 1,2,3,†, 1,2,3,†, Tao Xu 1,2,3,* and Lei Zhang 1,2,3,*
1
Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
2
Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, China
3
“Biomanufacturing and Engineering Living Systems” Innovation International Talents Base (111 Base), Beijing 100084, China
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Appl. Sci. 2019, 9(14), 2864; https://doi.org/10.3390/app9142864
Received: 10 June 2019 / Revised: 13 July 2019 / Accepted: 16 July 2019 / Published: 18 July 2019
(This article belongs to the Special Issue Biofabrication: From Additive Bio-Manufacturing to Bioprinting)
Tissue-engineered vascular grafts (TEVGs) are considered one of the most effective means of fabricating vascular grafts. However, for small-diameter TEVGs, there are ongoing issues regarding long-term patency and limitations related to long-term in vitro culture and immune reactions. The use of acellular TEVG is a more convincing method, which can achieve in situ blood vessel regeneration and better meet clinical needs. This review focuses on the current state of acellular TEVGs based on scaffolds and gives a summary of the methodologies and in vitro/in vivo test results related to acellular TEVGs obtained in recent years. Various strategies for improving the properties of acellular TEVGs are also discussed. View Full-Text
Keywords: vascular graft; tissue engineering; acellular; small diameter; in situ vascular graft; tissue engineering; acellular; small diameter; in situ
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MDPI and ACS Style

Li, Z.; Li, X.; Xu, T.; Zhang, L. Acellular Small-Diameter Tissue-Engineered Vascular Grafts. Appl. Sci. 2019, 9, 2864.

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