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Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

1
Faculty of Engineering and Natural Sciences, Sabanci University, 34956 Istanbul, Turkey
2
Nanotechnology Research and Application Center, Sabanci University, 34956 Istanbul, Turkey
3
Integrated Manufacturing Technologies Research and Application Center, Sabanci University, 34906 Istanbul, Turkey
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(17), 3540; https://doi.org/10.3390/app9173540
Received: 30 July 2019 / Revised: 17 August 2019 / Accepted: 22 August 2019 / Published: 28 August 2019
(This article belongs to the Special Issue Biofabrication: From Additive Bio-Manufacturing to Bioprinting)
Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted. View Full-Text
Keywords: melt electrospinning writing; hybrid biomanufacturing; three-dimensional scaffold; tissue engineering melt electrospinning writing; hybrid biomanufacturing; three-dimensional scaffold; tissue engineering
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MDPI and ACS Style

Afghah, F.; Dikyol, C.; Altunbek, M.; Koc, B. Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing. Appl. Sci. 2019, 9, 3540.

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