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Appl. Sci. 2018, 8(9), 1567; https://doi.org/10.3390/app8091567

Biodegradable Contrast Agents for Photoacoustic Imaging

1
Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeollanam-do 58128, Korea
2
Alan G. MacDiarmid Energy Research Institute, School of Polymer Science and Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea
3
Department of Nuclear Medicine, Chonnam National University Medical School, 264, Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeollanam-do 58128, Korea
*
Authors to whom correspondence should be addressed.
Received: 22 August 2018 / Revised: 3 September 2018 / Accepted: 3 September 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Recent Trends in Polymer Nanoscience and Nanotechnology)
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Abstract

Over the past twenty years, photoacoustics—also called optoacoustics—have been widely investigated and, in particular, extensively applied in biomedical imaging as an emerging modality. Photoacoustic imaging (PAI) detects an ultrasound wave that is generated via photoexcitation and thermoelastic expansion by a short nanosecond laser pulse, which significantly reduces light and acoustic scattering, more than in other typical optical imaging and renders high-resolution tomographic images with preserving high absorption contrast with deep penetration depth. In addition, PAI provides anatomical and physiological parameters in non-invasive manner. Over the past two decades, this technique has been remarkably developed in the sense of instrumentation and contrast agent materials. In this review, we briefly introduce state-of-the-art multiscale imaging systems and summarize recent progress on exogenous bio-compatible and -degradable agents that address biomedical application and clinical practice. View Full-Text
Keywords: photoacoustic imaging; biodegradable; melanoidin; carbon dots; gold nanoparticles; polymers photoacoustic imaging; biodegradable; melanoidin; carbon dots; gold nanoparticles; polymers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Yoo, S.W.; Jung, D.; Min, J.-J.; Kim, H.; Lee, C. Biodegradable Contrast Agents for Photoacoustic Imaging. Appl. Sci. 2018, 8, 1567.

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