Review Reports

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

In this review paper, authors focus on the mechanisms of Antarctic fungi to response to the oxidative stress induced by the extreme low temperature conditions. It is well organized with sufficient details. Authors may find several suggestions below when improving manuscript.

Some fungi that isolated in Antarctica are quite common in temperate habitats, e.g., Aspergillus, Penicillium, Fusarium, etc. I was curious if there are literatures talking about the evolution of these fungi in Antarctica and temperate habitats, and you might find some evolutionary evidence of genes that coding enzymes or proteins which response to oxidative stress. I would recommend adding this information to improve the manuscript.

L376 Delete “is limited”.

Author Response

Dear Reviewer,

Thank you very much for taking the time to review this manuscript. Please find the detailed responses below and the corresponding revisions highlighted in red in the re-submitted file.

Comment 1. L376 Delete “is limited”.

Response 1. The correction was made.

Comment 2. Some fungi that isolated in Antarctica are quite common in temperate habitats, e.g., Aspergillus, Penicillium, Fusarium, etc. I was curious if there are literatures talking about the evolution of these fungi in Antarctica and temperate habitats, and you might find some evolutionary evidence of genes that coding enzymes or proteins which response to oxidative stress. I would recommend adding this information to improve the manuscript.

Response 2. Thank you for this question. Given the importance of the problem, we have included in the review section entitled “Genetic basis of the cellular response to cold stress”. In the section, we have discussed published data on the importance of genes encoding enzymes that participate in the response to oxidative/cold stress. I would like to note that knowledge in this aspect is scarce, which requires a lot of new research.

Reviewer 2 Report

Comments and Suggestions for Authors

Work submitted to review entitled "Cell Response to Oxidative Stress in Antarctic Filamentous Fungi" describes the role of oxidative stress in cold-loving fungi and their adaptation to this environment. The work touches on interesting research issues. The structure of the manuscript is correct and introduces the reader to the subject of fungi living or isolated from Antarctica. The work presents the mechanisms of stress in great detail and explains the potential mechanisms of fungal adaptation to an unfavorable environment. 

Before accepting your work for publication, I suggest taking care of the editing side of the text. Sometimes you come across typos or double spaces.

I suggest adding a map of Antarctica with the most common mushroom isolation locations. This will allow the reader to visualize the location.   A good introduction to the article would be a graphic abstract.   I suggest the authors to try to prepare more diagrams with mechanisms of oxidative stress with metabolic pathways. The article contains few graphics.

Author Response

Response to Reviewer 2 Comments

Dear Reviewer,

Thank you for taking the time to review this manuscript. The detailed responses are provided below, and the relevant revisions are highlighted in red in the resubmitted file.

Comment 1. Before accepting your work for publication, I suggest taking care of the editing side of the text. Sometimes you come across typos or double spaces.

Response 1. The text was carefully checked. Any typographical errors and extra double spaces were corrected.

Comment 2. I suggest adding a map of Antarctica with the most common mushroom isolation locations. This will allow the reader to visualize the location.

Response 2. Thank you for your suggestion! It will be very useful but we think the map with sample locations will repeat information presented in Table 1.

Comment 3. A good introduction to the article would be a graphic abstract.

Response 3. Thank you for this idea. The graphic abstract was prepared.

Comment 4. I suggest the authors to try to prepare more diagrams with mechanisms of oxidative stress with metabolic pathways. The article contains few graphics.

Response 4. Five new figures were included in the text.