Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin

Round 1

Reviewer 1 Report

This study presents a case report of a phosphaturic mesenchymal tumor with osteomalacia. The manuscript is clear, relevant, and presented in a well-structured manner. The figures are appropriate and correctly show the diagnostic sequence of the case and the conclusion is consistent with the evidence and arguments presented. However, the references are more than 5 years old.

Author Response

First of all, we appreciate the reviewers for your precious time in reviewing our paper and providing valuable comments. We have carefully considered the comments and tried our best to address every one of them. We hope the manuscript after careful revisions meet your high standards.

Response to Reviewer 1 Comments

This study presents a case report of a phosphaturic mesenchymal tumor with osteomalacia. The manuscript is clear, relevant, and presented in a well-structured manner. The figures are appropriate and correctly show the diagnostic sequence of the case and the conclusion is consistent with the evidence and arguments presented. However, the references are more than 5 years old.

- We appreciate the comment. We have added the references published within 5 years.

Reviewer 2 Report

The article is interesting and well prepared. I found only some minor flaws:

26, 130 - use localization instead of disease

64 - sentence is confusing (which radiological features?)

178 - should be diagnosis instead of prognosis

205,206 - level of venous FGF23 can't localise the tumour. Should the sentence be: "Recently, venous sampling of FGF23 has been proposed as a method for definitive confirmation of the tumor secreting FGF23"? 

I miss latest rewiev of PMT in the reference list (https://doi.org/10.1053/j.semdp.2019.07.002)

Author Response

First of all, we appreciate the reviewers for your precious time in reviewing our paper and providing valuable comments. We have carefully considered the comments and tried our best to address every one of them. We hope the manuscript after careful revisions meet your high standards.

Response to Reviewer 2 Comments

26, 130 - use localization instead of disease

- As per your advice, terms have been modified.

64 - sentence is confusing (which radiological features?)

- As per your advice, sentence has been modified.

- In addition, a benign tumor of the jaws with radiological features which represent expanding while destroying the surrounding bone, including calcifying epithelial odontogenic tumor, calcifying odontogenic cyst, ossifying fibroma, central giant cell granuloma (CGCG) and brown tumor, could be considered.

178 - should be diagnosis instead of prognosis

- As per your advice, terms have been modified.

205,206 - level of venous FGF23 can't localise the tumour. Should the sentence be: "Recently, venous sampling of FGF23 has been proposed as a method for definitive confirmation of the tumor secreting FGF23"? 

- As per your advice, sentence has been modified.

I miss latest rewiev of PMT in the reference list (https://doi.org/10.1053/j.semdp.2019.07.002)

- We appreciate the comment. We revised the manuscript with reference to the above paper

Reviewer 3 Report

Dear Authors, 

this is very interesting case report but some changes have to be made. 

- change the Title so that it correlates with the conclusion: Tumor-induced osteomalacia as a result of a phosphaturic mesenchymal tumor: detecting rare origin

Introduction: - expand the general information about the tumor and write down how many cases there have been in the last 20 years

Second paragraph should be Case report and subtitles: Clinical presentation, Differential Diagnosis and Diagnosis and management

Discussion: - paragraph from line 142 to line 151 should be included in Introduction part

Author Response

First of all, we appreciate the reviewers for your precious time in reviewing our paper and providing valuable comments. We have carefully considered the comments and tried our best to address every one of them. We hope the manuscript after careful revisions meet your high standards.

Response to Reviewer 3 Comments

change the Title so that it correlates with the conclusion: Tumor-induced osteomalacia as a result of a phosphaturic mesenchymal tumor: detecting rare origin

- As per your advice, the Title has been modified.

Introduction: - expand the general information about the tumor and write down how many cases there have been in the last 20 years

Discussion: - paragraph from line 142 to line 151 should be included in Introduction part

- We appreciate the comment. We modified the Introduction and Discussion section as you advised.

Second paragraph should be Case report and subtitles: Clinical presentation, Differential Diagnosis and Diagnosis and management

- As per your advice, Second paragraph has been aligned as follows; Clinical presentation, Differential Diagnosis, Diagnosis and management.

Round 2

Reviewer 3 Report

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