The Power Setting of Focused Ultrasound for the Palliative Treatment of Advanced Pancreatic Cancer: A Study in an Ex Vivo Bovine Liver
Yoshifumi Saijo
Round 1
Reviewer 1 Report
A very well-conducted study with important impact on clinical practice.
Methodology is correct, methods well described, and figures comprehensive. I only suggest to add a comment on and spend a few word for comparison with others available ablation methods (RFA and IRE).
Doing so, cite PMID: 30505967
The Authors aimed to evaluate the temperature in the point of high intensity focused ultrasound (HIFU) application. To my knowledge, this is the first study on this topic, thus filling a gap in the field.
Moreover, it may have a relevant impact on clinical practice. I suggest Shortening the conclusion session and add a short paragraph on study limitation
Author Response
非常感谢您的宝贵意见。我已经根据你的意见修改了手稿。
- Introduction增加了RFA和IRE，PMID: 30505967被引用为参考文献15。
- 缩短了结论，并在最后一段添加了本研究的局限性。
Reviewer 2 Report
The authors investigated basis of moderate intensity focused ultrasound (MIFU) for the treatment of pancreatic cancer. In the paper they simulated and experimented MIFU temperature rise using bovine liver. The content is interesting however they need several revisions to the manuscript.
1. Title of the paper: Final objective would be the application of MIFU to palliative treatment of advanced pancreatic cancer. However, only bovine liver was used in the simulation and experiment. The title should be changed according to the contents of the paper.
2. During rapid increase of the temperature at the initial phase in Fig. 4-6, what has happened? Wasn’t it the cavitation effect?
3. Spacing is required between numerical value and unit. (i.e. 125W…)
Author Response
非常感谢您的宝贵意见。我已经根据你的意见修改了手稿。
- 文章标题已更改为：聚焦超声姑息治疗晚期胰腺癌的功率设置：离体牛肝的研究。
- 图4中，40W和125W的初始温度快速升高是由生物组织与红外玻璃之间的空化活动和粘性加热引起的。在图 5 和图 6 中，我们使用了低于空化阈值的声功率。初始温度的快速升高是由粘性加热引起的。我在原稿中没有描述清楚。谢谢您的意见。文章中已经解释了这种混淆。
- 在值和单位之间添加了间距。
