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Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art

Department of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Sauletekio al. 11, 10221 Vilnius, Lithuania
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Appl. Sci. 2020, 10(12), 4244; https://doi.org/10.3390/app10124244
Received: 2 June 2020 / Revised: 16 June 2020 / Accepted: 18 June 2020 / Published: 20 June 2020
(This article belongs to the Special Issue Electroporation Systems and Applications)
Electroporation is a pulsed electric field triggered phenomenon of cell permeabilization, which is extensively used in biomedical and biotechnological context. There is a growing scientific demand for high-voltage and/or high-frequency pulse generators for electropermeabilization of cells (electroporators). In the scope of this article we have reviewed the basic topologies of nanosecond pulsed electric field (nsPEF) generators for electroporation and the parametric capabilities of various in-house built devices, which were introduced in the last two decades. Classification of more than 60 various nsPEF generators was performed and pulse forming characteristics (pulse shape, voltage, duration and repetition frequency) were listed and compared. Lastly, the trends in the development of the electroporation technology were discussed. View Full-Text
Keywords: electroporation; electroporators; nanosecond pulsed electric fields; nsPEF; pulsed power devices; high frequency; MOSFET; capacitor discharge; Blumlein; high-voltage generators electroporation; electroporators; nanosecond pulsed electric fields; nsPEF; pulsed power devices; high frequency; MOSFET; capacitor discharge; Blumlein; high-voltage generators
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MDPI and ACS Style

Butkus, P.; Murauskas, A.; Tolvaišienė, S.; Novickij, V. Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art. Appl. Sci. 2020, 10, 4244. https://doi.org/10.3390/app10124244

AMA Style

Butkus P, Murauskas A, Tolvaišienė S, Novickij V. Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art. Applied Sciences. 2020; 10(12):4244. https://doi.org/10.3390/app10124244

Chicago/Turabian Style

Butkus, Paulius, Arūnas Murauskas, Sonata Tolvaišienė, and Vitalij Novickij. 2020. "Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art" Applied Sciences 10, no. 12: 4244. https://doi.org/10.3390/app10124244

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