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Open AccessArticle

Evaluation of the Dietary Supplementation of a Formulation Containing Ascorbic Acid and a Solid Dispersion of Curcumin with Boric Acid against Salmonella Enteritidis and Necrotic Enteritis in Broiler Chickens

1
Laboratorio 5: LEDEFAR, Unidad de Investigacion Multidisciplinaria, Facultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de México, Cuautitlan Izcalli 54714, Mexico
2
Departamento de Medicina Veterinária Preventiva, Centro de Diagnóstico e Pesquisa em Patologia Aviária, Universidade Federal do Rio Grande do Sul, Porto Alegre RS 97105-900, Brazil
3
Department of Poultry Science, University of Arkansas, Fayetteville, AR 72704, USA
4
Departamento de Medicina y Zootecnia de Aves, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
5
Laboratorio 14: Alimentos, Micotoxinas y Micotoxicosis, Unidad de Investigacion Multidisciplinaria, Facultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico, Cuautitlan Izcalli 54714, Mexico
*
Author to whom correspondence should be addressed.
Animals 2019, 9(4), 184; https://doi.org/10.3390/ani9040184
Received: 3 April 2019 / Revised: 18 April 2019 / Accepted: 18 April 2019 / Published: 22 April 2019
(This article belongs to the Special Issue Poultry Nutrition)
Prophylactic or therapeutic administration of a 0.1% mixture containing ascorbic acid (AA) and a solid dispersion of curcumin (CUR) with polyvinylpyrrolidone (PVP) and boric acid (BA) (AA-CUR/PVP-BA) significantly reduced the concentration of Salmonella Enteritidis in broiler chickens and had a positive effect in slightly diminishing the negative impact of necrotic enteritis (NE).
Two experiments were conducted to evaluate the effect of the prophylactic or therapeutic administration of a 0.1% mixture containing ascorbic acid and a solid dispersion of curcumin with polyvinylpyrrolidone and boric acid (AA-CUR/PVP-BA) against Salmonella Enteritidis (S. Enteritidis) in broiler chickens. A third experiment was conducted to evaluate the impact of the dietary administration of 0.1% AA-CUR/PVP-BA in a necrotic enteritis (NE) model in broiler chickens. The prophylactic administration of 0.1% AA-CUR/PVP-BA significantly decreased S. Enteritidis colonization in cecal tonsils (CT) when compared to the positive control group (PC, p < 0.05). The therapeutic administration of 0.1% AA-CUR/PVP-BA significantly reduced the concentration of S. Enteritidis by 2.05 and 2.71 log in crop and CT, respectively, when compared with the PC on day 10 post-S. Enteritidis challenge. Furthermore, the serum FITC-d concentration and total intestinal IgA levels were also significantly lower in chickens that received 0.1% AA-CUR/PVP-BA. Contrary, the PC group showed significantly higher total intestinal IgA levels compared to the negative control or AA-CUR/PVP-BA groups in the NE model. However, 0.1% AA-CUR/PVP-BA showed a better effect in reducing the concentration of S. Enteritidis when compared to the NE model. Further studies with higher concentration of AA-CUR/PVP-BA into the feed to extend these preliminary results are currently being evaluated. View Full-Text
Keywords: chickens; ascorbic acid; curcumin; boric acid; necrotic enteritis; Salmonella Enteritidis chickens; ascorbic acid; curcumin; boric acid; necrotic enteritis; Salmonella Enteritidis
MDPI and ACS Style

Hernandez-Patlan, D.; Solís-Cruz, B.; Patrin Pontin, K.; Latorre, J.D.; Baxter, M.F.A.; Hernandez-Velasco, X.; Merino-Guzman, R.; Méndez-Albores, A.; Hargis, B.M.; Lopez-Arellano, R.; Tellez-Isaias, G. Evaluation of the Dietary Supplementation of a Formulation Containing Ascorbic Acid and a Solid Dispersion of Curcumin with Boric Acid against Salmonella Enteritidis and Necrotic Enteritis in Broiler Chickens. Animals 2019, 9, 184.

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