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Article

Effects of Parenteral Supplementation with Minerals and Vitamins on Oxidative Stress and Humoral Immune Response of Weaning Calves

1
Laboratorio de Nutrición Mineral, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, calle 60 y 118 s/n, 1900 La Plata, Buenos Aires, Argentina
2
Biogenésis Bagó, Panamericana Km 38,5, B1619 Garín, Buenos Aires, Argentina
3
Laboratory of Animal Health, LARSANA, Federal University of Western Pará, UFOPA, Rua Vera Paz, s/n, 68040-255 Santarém, Pará, Brazil
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LAPEVET-Laboratorio de Patología Especial Veterinaria (FCV-UNLP), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, calle 60 y 118 s/n, 1900 La Plata, Argentina
*
Authors to whom correspondence should be addressed.
Animals 2020, 10(8), 1298; https://doi.org/10.3390/ani10081298
Received: 16 June 2020 / Revised: 16 July 2020 / Accepted: 28 July 2020 / Published: 29 July 2020
Weaning is a stressful phase for calves; the stress due to separation from the cow results in weight loss and may lead to a decrease in the immune system, making calves more prone to diseases, even in a low-stress (fence-line) weaning system. Mineral and vitamin supplementation can improve the immune system and could therefore be of assistance for calves during weaning. We studied the effects of injectable (subcutaneous) supplementation with copper, zinc, selenium, manganese, and vitamins A and E. Calves were supplemented twice, before weaning and on the day of weaning. We evaluated variables related to the immune status and the immune response to a vaccine containing bovine herpesvirus type 1, as well as body weight and average daily gain. Parenteral supplementation of minerals and vitamins with antioxidant effects in a low-stress weaning system prevented the decrease in variables related to the immune system, improved antibody response, and had positive effects on body weight.
We aimed to evaluate the effects of injectable mineral and vitamin supplementation on weaning calves subjected to a low-stress (fence-line) weaning system. Seven-month-old Aberdeen Angus female calves (n = 40, 152 ± 11 kg body weight) from a selenium-deficient area of extensive cattle production on natural grass were randomly assigned to two groups (n = 20 each). One group received subcutaneous supplementation with copper, zinc, selenium, manganese and vitamins A and E (SG), and the other was given sterile saline solution (CG). The animals were supplemented twice, seven days before weaning (day −7) and on the day of weaning (day 0), and they were evaluated 30 (+30) and 60 (+60) days after weaning. Total antioxidant status (TAS), selenium-dependent glutathione peroxidase (GPx) activity, body weight, and average daily gain (ADG) were evaluated. Additionally, antibody titers were assessed prior to and after each immunization with a vaccine containing bovine herpes virus type 1 (BoHV-1). On day +30, body weight (p = 0.03) was higher in SG, whereas TAS (p = 0.02) and GPx (p = 0.0038) activity were lower in CG and remained constant in SG. Antibody titers increased in SG and CG following immunization, being higher in SG on days +30 and +60 (p < 0.05). In conclusion, parenteral supplementation of minerals and vitamins with antioxidant effects in a low-stress weaning system prevented the decrease in TAS and GPx activity, improved antibody response and had positive effects on body weight. View Full-Text
Keywords: beef calf; immune response; oxidative stress; weaning; weight gain beef calf; immune response; oxidative stress; weaning; weight gain
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MDPI and ACS Style

Mattioli, G.A.; Rosa, D.E.; Turic, E.; Picco, S.J.; Raggio, S.J.; Minervino, A.H.H.; Fazzio, L.E. Effects of Parenteral Supplementation with Minerals and Vitamins on Oxidative Stress and Humoral Immune Response of Weaning Calves. Animals 2020, 10, 1298. https://doi.org/10.3390/ani10081298

AMA Style

Mattioli GA, Rosa DE, Turic E, Picco SJ, Raggio SJ, Minervino AHH, Fazzio LE. Effects of Parenteral Supplementation with Minerals and Vitamins on Oxidative Stress and Humoral Immune Response of Weaning Calves. Animals. 2020; 10(8):1298. https://doi.org/10.3390/ani10081298

Chicago/Turabian Style

Mattioli, Guillermo A., Diana E. Rosa, Esteban Turic, Sebastián J. Picco, Santiago J. Raggio, Antonio H.H. Minervino, and Luis E. Fazzio 2020. "Effects of Parenteral Supplementation with Minerals and Vitamins on Oxidative Stress and Humoral Immune Response of Weaning Calves" Animals 10, no. 8: 1298. https://doi.org/10.3390/ani10081298

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