Next Article in Journal
Morphometric Characteristics of the Spermatozoa of Blue Fox (Alopex lagopus) and Silver Fox (Vulpes vulpes)
Next Article in Special Issue
Effects of Dietary Crude Protein Levels on Fecal Crude Protein, Amino Acids Flow Amount, Fecal and Ileal Microbial Amino Acids Composition and Amino Acid Digestibility in Growing Pigs
Previous Article in Journal
Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
Previous Article in Special Issue
Effects of a Grain Source (Corn Versus Barley) and Starter Protein Content on Performance, Ruminal Fermentation, and Blood Metabolites in Holstein Dairy Calves
Open AccessArticle

A Novel Corn-Expressed Phytase Improves Daily Weight Gain, Protein Efficiency Ratio and Nutrients Digestibility and Alters Fecal Microbiota in Pigs Fed with Very Low Protein Diets

1
Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USA
2
Agrivida, Woburn, MA 01801, USA
*
Author to whom correspondence should be addressed.
Animals 2020, 10(10), 1926; https://doi.org/10.3390/ani10101926
Received: 8 September 2020 / Revised: 7 October 2020 / Accepted: 17 October 2020 / Published: 20 October 2020
Feeding pigs with very low crude protein (CP) diets with reduced calcium (Ca) and phosphorous (P) may be an effective strategy to decrease the nutrient excretion; however, this practice can negatively impact the growth performance of animals. Thus, there is an urgent need to improve the utilization of nitrogen, Ca and P in pigs. This study aimed to assess the effect of a novel corn-expressed phytase on growth performance, nutrients digestibility, gut microbial population, bone mineral density and content and blood metabolites in nursery pigs fed with low-CP, -Ca, and -P diets. Supplementation of very low protein diets with a corn-expressed phytase decreased the negative effects of these diets on average daily gain and protein efficiency ratio of pigs, increased the digestibility of Ca and P regardless of the levels of these minerals in the diet, improved bone characteristics and altered the fecal bacterial composition. This study suggests that corn-expressed phytase can be potentially useful for improving the growth performance of weaned pigs fed with low protein diets and should be considered for sustainable swine production.
The objective of this study was to assess the effect of a novel corn-expressed phytase (CEP) on growth, nutrients digestibility, bone characteristics and fecal microbiota of pigs fed with very low-protein, -calcium (Ca) and -phosphorous (P) diets. Forty-eight barrows were subjected to 6 groups for 4 weeks: positive control-adequate protein (PC), negative control-reduced protein (NC), NC + low-dose CEP, i.e., 2000 FTU/kg (LD), NC + high-dose CEP, i.e., 4000 FTU/kg (HD), LD with 0.12% unit reduced Ca and 0.15% unit reduced available P (LDR), and HD with 0.12% unit reduced Ca and 0.15% unit reduced available P (HDR). Compared to NC, LD and HDR had a higher average daily gain (ADG) and gain:protein ratio (G:P), HD and HDR had greater apparent fecal digestibility of Ca and P and bone mineral density and LDR and HDR had lower serum osteocalcin. The feces of LD was enriched in Lachnospiraceae, while the HD had a higher abundance of Succinvibrio and LDR had a higher abundance of Bifidobacterium and Actinobacteria. In conclusion, supplementation of protein-restricted diets with a CEP decreased their negative effects on ADG and G:P ratio, increased the digestibility of Ca and P regardless of the levels of these minerals in the diet, improved bone characteristics and produced differential effects on fecal bacterial population. View Full-Text
Keywords: low-protein diets; low calcium/phosphorous diets; corn-expressed phytase; growth; nutrients digestibility; bone characteristics; fecal microbiota; pigs low-protein diets; low calcium/phosphorous diets; corn-expressed phytase; growth; nutrients digestibility; bone characteristics; fecal microbiota; pigs
Show Figures

Graphical abstract

MDPI and ACS Style

Shili, C.N.; Broomhead, J.N.; Spring, S.C.; Lanahan, M.B.; Pezeshki, A. A Novel Corn-Expressed Phytase Improves Daily Weight Gain, Protein Efficiency Ratio and Nutrients Digestibility and Alters Fecal Microbiota in Pigs Fed with Very Low Protein Diets. Animals 2020, 10, 1926.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop