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Open AccessArticle

The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability

by 1,†, 2,†, 1, 1, 1 and 1,*
1
School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China
2
Department of Biological and Environmental Engineering, Hefei University, Hefei 230032, Anhui, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Microorganisms 2020, 8(2), 211; https://doi.org/10.3390/microorganisms8020211
Received: 16 December 2019 / Revised: 29 January 2020 / Accepted: 31 January 2020 / Published: 5 February 2020
(This article belongs to the Collection Feature Papers in Gut Microbiota)
Cadmium (Cd), widely present in food and drinking water at low doses, can cause health risks. However, the mechanistic effects of long-term Cd exposure at low dose through dietary intake is poorly studied. The aim of this study is to elucidate whether the dysbiosis of gut microbiota caused by Cd at an environmental low dose can aggravate the injury of mice liver, and the possible mechanism is investigated. In order to explore the potential underlying mechanism, the analyses of the variation of gut microbiota composition, intestinal permeability, and hepatic transcriptome were conducted. Our results showed that gut microbiota was disturbed. The rise of intestinal permeability induced by the dysbiosis of gut microbiota resulted in more Cd ions accumulating in mice liver, but it could be restored partly through depleting gut microbiota by antibiotics cocktail. Transcriptomic analyses indicated that 162 genes were significantly differentially expressed including 59 up-regulated and 103 down-regulated in Cd treatment. These genes were involved in several important pathways. Our findings provide a better understanding about the health risks of cadmium in the environment. View Full-Text
Keywords: transcriptome analyses; gut microbiota; cadmium; intestinal permeability transcriptome analyses; gut microbiota; cadmium; intestinal permeability
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MDPI and ACS Style

Liu, Y.; Li, Y.; Xia, Y.; Liu, K.; Ren, L.; Ji, Y. The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability. Microorganisms 2020, 8, 211. https://doi.org/10.3390/microorganisms8020211

AMA Style

Liu Y, Li Y, Xia Y, Liu K, Ren L, Ji Y. The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability. Microorganisms. 2020; 8(2):211. https://doi.org/10.3390/microorganisms8020211

Chicago/Turabian Style

Liu, Yehao; Li, Yuhui; Xia, Yuhong; Liu, Kaiyong; Ren, Lingling; Ji, Yanli. 2020. "The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability" Microorganisms 8, no. 2: 211. https://doi.org/10.3390/microorganisms8020211

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