Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations

Quagliariello, Andrea; Del Chierico, Federica; Reddel, Sofia; Russo, Alessandra; Onetti Muda, Andrea; D’Argenio, Patrizia; Angelino, Giulia; Romeo, Erminia Francesca; Dall’Oglio, Luigi; De Angelis, Paola; Putignani, Lorenza; all the other FMT OPBG Committee Collaborators,

doi:10.3390/microorganisms8101486

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Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations

by

Andrea Quagliariello

^1,†

,

Federica Del Chierico

^1,*,†

,

Sofia Reddel

¹,

Alessandra Russo

²,

Andrea Onetti Muda

³,

Patrizia D’Argenio

⁴,

Giulia Angelino

⁵,

Erminia Francesca Romeo

⁵,

Luigi Dall’Oglio

⁵,

Paola De Angelis

⁵,

Lorenza Putignani

⁶

and

all the other FMT OPBG Committee Collaborators

^‡,§

¹

Area of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy

²

Department of Laboratories, Unit of Parasitology, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy

³

Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy

⁴

Academic Department of Pediatrics, Unit of Immune and Infectious Diseases, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy

⁵

Digestive Surgery and Endoscopy Unit, Bambino Gesù Children’s Hospital IRCCS, 00165 Rome, Italy

⁶

Department of Laboratories, Unit of Parasitology and Area of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy

^*

Author to whom correspondence should be addressed.

^†

These authors equally contributed to this work.

^‡

Commettee collaborators are: Paola Bernaschi, Simona Faraci, Andrea Finocchi, Gianluca Foglietta, Livia Gargiullo, Sandra Martino, Giulia Marucci, Pietro Merli, Stefania Pane, Francesca Rea, Giuliano Torre, Filippo Torroni and Valerio Nobili.

^§

This paper is dedicated to the lovely memory of Professor Valerio Nobili.

Microorganisms 2020, 8(10), 1486; https://doi.org/10.3390/microorganisms8101486

Submission received: 31 August 2020 / Revised: 11 September 2020 / Accepted: 23 September 2020 / Published: 27 September 2020

(This article belongs to the Special Issue Therapeutic Potential of Fecal Microbiota Therapy (FMT))

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Abstract

Fecal microbiota transplantation (FMT) is a promising strategy in the management of inflammatory bowel disease (IBD). The clinical effects of this practice are still largely unknown and unpredictable. In this study, two children affected by mild and moderate ulcerative colitis (UC), were pre- and post-FMT monitored for clinical conditions and gut bacterial ecology. Microbiota profiling relied on receipts’ time-point profiles, donors and control cohorts’ baseline descriptions. After FMT, the improvement of clinical conditions was recorded for both patients. After 12 months, the mild UC patient was in clinical remission, while the moderate UC patient, after 12 weeks, had a clinical worsening. Ecological analyses highlighted an increase in microbiota richness and phylogenetic distance after FMT. This increase was mainly due to Collinsella aerofaciens and Eubacterium biforme, inherited by respective donors. Moreover, a decrease of Proteus and Blautia producta, and the increment of Parabacteroides, Mogibacteriaceae, Bacteroides eggerthi, Bacteroides plebeius, Ruminococcus bromii, and BBacteroidesovatus were associated with remission of the patient’s condition. FMT results in a long-term response in mild UC, while in the moderate form there is probably need for multiple FMT administrations. FMT leads to a decrease in potential pathogens and an increase in microorganisms correlated to remission status.

Keywords: gut microbiota; fecal microbiota transplantation (FMT); Pediatric Ulcerative Colitis (UC); inflammatory bowel disease (IBD); gut bacterial ecology

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MDPI and ACS Style

Quagliariello, A.; Del Chierico, F.; Reddel, S.; Russo, A.; Onetti Muda, A.; D’Argenio, P.; Angelino, G.; Romeo, E.F.; Dall’Oglio, L.; De Angelis, P.; et al. Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations. Microorganisms 2020, 8, 1486. https://doi.org/10.3390/microorganisms8101486

AMA Style

Quagliariello A, Del Chierico F, Reddel S, Russo A, Onetti Muda A, D’Argenio P, Angelino G, Romeo EF, Dall’Oglio L, De Angelis P, et al. Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations. Microorganisms. 2020; 8(10):1486. https://doi.org/10.3390/microorganisms8101486

Chicago/Turabian Style

Quagliariello, Andrea, Federica Del Chierico, Sofia Reddel, Alessandra Russo, Andrea Onetti Muda, Patrizia D’Argenio, Giulia Angelino, Erminia Francesca Romeo, Luigi Dall’Oglio, Paola De Angelis, and et al. 2020. "Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations" Microorganisms 8, no. 10: 1486. https://doi.org/10.3390/microorganisms8101486

APA Style

Quagliariello, A., Del Chierico, F., Reddel, S., Russo, A., Onetti Muda, A., D’Argenio, P., Angelino, G., Romeo, E. F., Dall’Oglio, L., De Angelis, P., Putignani, L., & all the other FMT OPBG Committee Collaborators. (2020). Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations. Microorganisms, 8(10), 1486. https://doi.org/10.3390/microorganisms8101486

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Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations

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