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Review

Mutation and Recombination Rates Vary Across Bacterial Chromosome

Chair of Genetics, Institute of Molecular and Cell Biology, University of Tartu, 23 Riia Street, 51010 Tartu, Estonia
Microorganisms 2020, 8(1), 25; https://doi.org/10.3390/microorganisms8010025
Received: 28 November 2019 / Revised: 18 December 2019 / Accepted: 19 December 2019 / Published: 21 December 2019
Bacteria evolve as a result of mutations and acquisition of foreign DNA by recombination processes. A growing body of evidence suggests that mutation and recombination rates are not constant across the bacterial chromosome. Bacterial chromosomal DNA is organized into a compact nucleoid structure which is established by binding of the nucleoid-associated proteins (NAPs) and other proteins. This review gives an overview of recent findings indicating that the mutagenic and recombination processes in bacteria vary at different chromosomal positions. Involvement of NAPs and other possible mechanisms in these regional differences are discussed. Variations in mutation and recombination rates across the bacterial chromosome may have implications in the evolution of bacteria. View Full-Text
Keywords: mutation rate; homologous recombination; mutation accumulation; bacterial chromosome structure; nucleoid-associated proteins; evolution mutation rate; homologous recombination; mutation accumulation; bacterial chromosome structure; nucleoid-associated proteins; evolution
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MDPI and ACS Style

Kivisaar, M. Mutation and Recombination Rates Vary Across Bacterial Chromosome. Microorganisms 2020, 8, 25. https://doi.org/10.3390/microorganisms8010025

AMA Style

Kivisaar M. Mutation and Recombination Rates Vary Across Bacterial Chromosome. Microorganisms. 2020; 8(1):25. https://doi.org/10.3390/microorganisms8010025

Chicago/Turabian Style

Kivisaar, Maia. 2020. "Mutation and Recombination Rates Vary Across Bacterial Chromosome" Microorganisms 8, no. 1: 25. https://doi.org/10.3390/microorganisms8010025

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