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Microorganisms
Volume 8
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10.3390/microorganisms8010014
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Review

PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma

by
Giuseppe Riva
1,
Matteo Biolatti
2,
Giancarlo Pecorari
1,
Valentina Dell’Oste
2 and
Santo Landolfo
2,*
1
Otorhinolaryngology Division, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy
2
Laboratory of Pathogenesis of Viral Infections, Department of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(1), 14; https://doi.org/10.3390/microorganisms8010014
Submission received: 4 November 2019 / Revised: 11 December 2019 / Accepted: 18 December 2019 / Published: 20 December 2019
(This article belongs to the Special Issue Virus-Host Interaction: From Physiology to Pathology)
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Abstract

In the last decades, the human papillomavirus (HPV) emerged as an etiological cause of head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible protein 16 (IFI16) and absent in melanoma 2 protein (AIM2)), has been analyzed in relation to HPV infection and head and neck carcinogenesis. In particular, IFI16 and AIM2 expression depends on HPV infection in HNSCC. They represent viral restriction factors and are key components of the intrinsic immunity activated against different viruses, including HPV. This review analyzed and summarized the recent findings about the role of PYHIN proteins in HPV+ and HPV− HNSCC.
Keywords: HPV; head and neck cancer; PYHIN proteins; IFI16; AIM2 HPV; head and neck cancer; PYHIN proteins; IFI16; AIM2

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MDPI and ACS Style

Riva, G.; Biolatti, M.; Pecorari, G.; Dell’Oste, V.; Landolfo, S. PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma. Microorganisms 2020, 8, 14. https://doi.org/10.3390/microorganisms8010014

AMA Style

Riva G, Biolatti M, Pecorari G, Dell’Oste V, Landolfo S. PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma. Microorganisms. 2020; 8(1):14. https://doi.org/10.3390/microorganisms8010014

Chicago/Turabian Style

Riva, Giuseppe, Matteo Biolatti, Giancarlo Pecorari, Valentina Dell’Oste, and Santo Landolfo. 2020. "PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma" Microorganisms 8, no. 1: 14. https://doi.org/10.3390/microorganisms8010014

APA Style

Riva, G., Biolatti, M., Pecorari, G., Dell’Oste, V., & Landolfo, S. (2020). PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma. Microorganisms, 8(1), 14. https://doi.org/10.3390/microorganisms8010014

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