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Open AccessArticle

Oncogenic Virome Benefits from the Different Vaginal Microbiome-Immune Axes

1
Advanced Laboratory of Translational Microbiology, Institute for maternal and child health “IRCCS Burlo Garofolo”, Via dell’Istria 65, 34137 Trieste, Italy
2
Infections and Cancer Biology Group, IARC, 150 Cours Albert Thomas, 69008 Lyon, France
3
Obstetrics and Gynecology, Institute for maternal and child health “IRCCS Burlo Garofolo”, Via dell’Istria 65, 34137 Trieste, Italy
4
Department of Medical Sciences, UNITS Cattinara Hospital, Strada di Fiume 447, 34149 Trieste, Italy
5
Laboratory of Translational Research, Department of Biomedical, Surgical and Dental Sciences, University of Milano, Via Carlo Pascal, 36, 20133 Milano, Italy
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(10), 414; https://doi.org/10.3390/microorganisms7100414
Received: 5 September 2019 / Revised: 27 September 2019 / Accepted: 30 September 2019 / Published: 1 October 2019
(This article belongs to the Special Issue Virus-Host Interaction: From Physiology to Pathology)
The picture of dynamic interaction between oncogenic viruses and the vaginal bacteria-immune host milieu is incomplete. We evaluated the impact of Polyomaviridae, Papillomaviridae, and Herpesviridae oncoviruses on the vaginal Community State Types (CSTs) and host immune response in reproductive-age women. In our cohort, only Polyomaviridae and Papillomaviridae were detected and were associated with changes in the resident bacteria of CST I and IV (p < 0.05). Lactobacillus crispatus increased in CST I while Prevotella timonensis and Sneathia sanguinegens increased in CST IV. Conversely, CST II and III showed an alteration of the immune response, with the decrease of Eotaxin, MCP-1, IL-7, IL-9, and IL-15 (p < 0.05), leading to reduced antiviral efficacy. An efficient viral clearance was observed only in women from CST I, dominated by Lactobacillus crispatus. Our in vivo study begins to address the knowledge gap with respect to the role of vaginal bacteria and immune response in susceptibility to oncoviral infections. View Full-Text
Keywords: virome; bacteriome; immune response; vagitypes virome; bacteriome; immune response; vagitypes
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MDPI and ACS Style

Campisciano, G.; Gheit, T.; De Seta, F.; Cason, C.; Zanotta, N.; Delbue, S.; Ricci, G.; Ferrante, P.; Tommasino, M.; Comar, M. Oncogenic Virome Benefits from the Different Vaginal Microbiome-Immune Axes. Microorganisms 2019, 7, 414.

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