A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species
Abstract
:1. Introduction
2. Materials and Methods
2.1. Strains, Media, Chemicals and Growth Conditions
2.2. Spot Dilution and Liquid Survival/Growth Inhibition Assays
2.3. Immunoblotting
2.4. XTT Viability Assay
2.5. Macrophage Survival Assay
3. Results
3.1. CPTH2 Inhibits C. albicans Growth
3.2. Growth Inhibition by CPTH2 is Gcn5 Independent
3.3. CPTH2 Specifically Inhibits CTG Clade Candida Species
3.4. CPTH2 Protects Macrophages from Candida-Mediated Killing
4. Discussion
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Tscherner, M.; Kuchler, K. A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species. Microorganisms 2019, 7, 201. https://doi.org/10.3390/microorganisms7070201
Tscherner M, Kuchler K. A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species. Microorganisms. 2019; 7(7):201. https://doi.org/10.3390/microorganisms7070201
Chicago/Turabian StyleTscherner, Michael, and Karl Kuchler. 2019. "A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species" Microorganisms 7, no. 7: 201. https://doi.org/10.3390/microorganisms7070201