Next Article in Journal
Bioreactor-Scale Strategies for the Production of Recombinant Protein in the Yeast Yarrowia lipolytica
Previous Article in Journal
The Form of N Supply Determines Plant Growth Promotion by P-Solubilizing Microorganisms in Maize
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Microorganisms 2019, 7(2), 39; https://doi.org/10.3390/microorganisms7020039

Candida glabrata: A Lot More Than Meets the Eye

1
Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500039, India
2
Graduate Studies, Manipal Academy of Higher Education, Manipal 576104, India
3
Graduate Studies, Regional Centre for Biotechnology, Faridabad 121001, India
*
Author to whom correspondence should be addressed.
Received: 19 December 2018 / Revised: 21 January 2019 / Accepted: 29 January 2019 / Published: 30 January 2019
(This article belongs to the Special Issue Molecular Mechanisms of Fungal Virulence and Commensalism)
Full-Text   |   PDF [1969 KB, uploaded 30 January 2019]   |  

Abstract

Candida glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in individuals with a compromised immune system. Evolutionarily, it is closer to the non-pathogenic yeast Saccharomyces cerevisiae than to the most prevalent Candida bloodstream pathogen, C. albicans. C. glabrata is a haploid budding yeast that predominantly reproduces clonally. In this review, we summarize interactions of C. glabrata with the host immune, epithelial and endothelial cells, and the ingenious strategies it deploys to acquire iron and phosphate from the external environment. We outline various attributes including cell surface-associated adhesins and aspartyl proteases, biofilm formation and stress response mechanisms, that contribute to the virulence of C. glabrata. We further discuss how, C. glabrata, despite lacking morphological switching and secreted proteolytic activity, is able to disarm macrophage, dampen the host inflammatory immune response and replicate intracellularly. View Full-Text
Keywords: Candida glabrata; yeast pathogens; adherence; biofilm formation; aspartyl proteases; stress response mechanisms; host immune cells Candida glabrata; yeast pathogens; adherence; biofilm formation; aspartyl proteases; stress response mechanisms; host immune cells
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kumar, K.; Askari, F.; Sahu, M.S.; Kaur, R. Candida glabrata: A Lot More Than Meets the Eye. Microorganisms 2019, 7, 39.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top