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Microorganisms 2019, 7(2), 39;

Candida glabrata: A Lot More Than Meets the Eye

Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500039, India
Graduate Studies, Manipal Academy of Higher Education, Manipal 576104, India
Graduate Studies, Regional Centre for Biotechnology, Faridabad 121001, India
Author to whom correspondence should be addressed.
Received: 19 December 2018 / Revised: 21 January 2019 / Accepted: 29 January 2019 / Published: 30 January 2019
(This article belongs to the Special Issue Molecular Mechanisms of Fungal Virulence and Commensalism)
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Candida glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in individuals with a compromised immune system. Evolutionarily, it is closer to the non-pathogenic yeast Saccharomyces cerevisiae than to the most prevalent Candida bloodstream pathogen, C. albicans. C. glabrata is a haploid budding yeast that predominantly reproduces clonally. In this review, we summarize interactions of C. glabrata with the host immune, epithelial and endothelial cells, and the ingenious strategies it deploys to acquire iron and phosphate from the external environment. We outline various attributes including cell surface-associated adhesins and aspartyl proteases, biofilm formation and stress response mechanisms, that contribute to the virulence of C. glabrata. We further discuss how, C. glabrata, despite lacking morphological switching and secreted proteolytic activity, is able to disarm macrophage, dampen the host inflammatory immune response and replicate intracellularly. View Full-Text
Keywords: Candida glabrata; yeast pathogens; adherence; biofilm formation; aspartyl proteases; stress response mechanisms; host immune cells Candida glabrata; yeast pathogens; adherence; biofilm formation; aspartyl proteases; stress response mechanisms; host immune cells

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Kumar, K.; Askari, F.; Sahu, M.S.; Kaur, R. Candida glabrata: A Lot More Than Meets the Eye. Microorganisms 2019, 7, 39.

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