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Animal Models of Lassa Fever
Open AccessEditorial

Lassa Fever: Viral Replication, Disease Pathogenesis, and Host Immune Modulations

by Hinh Ly
Department of Veterinary Biomedical Sciences, University of Minnesota, Twin Cities, 1988 Fitch Ave., Ste. 295, Saint Paul, MN 55108, USA
Pathogens 2020, 9(6), 437; https://doi.org/10.3390/pathogens9060437
Received: 28 May 2020 / Accepted: 2 June 2020 / Published: 3 June 2020
Despite major discoveries made in the last few decades about Lassa fever, there are still many unresolved key issues that hamper the development of effective vaccines and therapies against this deadly disease that is endemic in several West African countries. Some of these issues include the lack of a detailed understanding of the viral and participating host factors in completing the virus life cycle, in mediating disease pathogenesis or protection from disease, and in activating or suppressing host innate and cellular immunity against virus infection, as well as of the animal models required for testing vaccines and therapeutics. This Special Issue is devoted to understanding some of these important issues and to exploring the current status of the research and development in combating Lassa fever. View Full-Text
Keywords: Lassa virus; arenavirus; mammarenavirus; vaccine; virulence; pathogenesis; innate immunity; adaptive immunity; COVID-19 Lassa virus; arenavirus; mammarenavirus; vaccine; virulence; pathogenesis; innate immunity; adaptive immunity; COVID-19
MDPI and ACS Style

Ly, H. Lassa Fever: Viral Replication, Disease Pathogenesis, and Host Immune Modulations. Pathogens 2020, 9, 437.

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