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The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland

1
Department of Virology, University of Helsinki and Helsinki University Hospital, PO Box 21, FI-00014 Helsinki, Finland
2
Faculty of Social Sciences, Tampere University, PO Box 100, FI-33014 Tampere, Finland
3
Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, PO Box 140, FI-00029 HUS Helsinki, Finland
4
Department of Laboratory Medicine, Karolinska Institute, Alfred Nobels Allé 8, 14183 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
The authors contributed equally to this study.
Pathogens 2019, 8(4), 276; https://doi.org/10.3390/pathogens8040276
Received: 30 October 2019 / Revised: 28 November 2019 / Accepted: 29 November 2019 / Published: 1 December 2019
(This article belongs to the Special Issue Chlamydia trachomatis Infections)
Chlamydia trachomatis, Mycoplasma genitalium, herpes simplex virus (HSV) and human papillomavirus (HPV) cause sexually transmitted infections. In addition, human herpesvirus 6 (HHV-6) may be a genital co-pathogen. The prevalence rates of HSV, HHV-6, HPV, M. genitalium, and the C. trachomatis ompA genotypes were investigated by PCR in urogenital samples of the C. trachomatis nucleic acid amplification test positive (n = 157) and age-, community- and time-matched negative (n = 157) women. The prevalence of HPV DNA was significantly higher among the C. trachomatis positives than the C. trachomatis negatives (66% vs. 25%, p < 0.001). The prevalence of HSV (1.9% vs. 0%), HHV-6 (11% vs. 14%), and M. genitalium DNA (4.5% vs. 1.9%) was not significantly different between the C. trachomatis-positive and -negative women. Thirteen per cent of test-of-cure specimens tested positive for C. trachomatis. The prevalence of HSV, HHV-6, HPV, M. genitalium, and the C. trachomatis ompA genotypes did not significantly differ between those who cleared the C. trachomatis infection (n = 105) and those who did not (n = 16). The higher prevalence of HPV DNA among the C. trachomatis positives suggests greater sexual activity and increased risk for sexually transmitted pathogens. View Full-Text
Keywords: sexually transmitted infection; chlamydial co-infection sexually transmitted infection; chlamydial co-infection
MDPI and ACS Style

Korhonen, S.; Hokynar, K.; Eriksson, T.; Natunen, K.; Paavonen, J.; Lehtinen, M.; Puolakkainen, M. The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland. Pathogens 2019, 8, 276.

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