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Open AccessArticle

Advances in Legionella Control by a New Formulation of Hydrogen Peroxide and Silver Salts in a Hospital Hot Water Network

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Department of Biological, Geological, and Environmental Sciences, BiGeA, University of Bologna, 40126 Bologna, Italy
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Department of Medical and Surgical Science, DIMEC, University of Bologna, 40126 Bologna, Italy
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GVM Care & Research, Lugo di Ravenna, 48022 Ravenna, Italy
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Eta-Beta S.r.l., 47122 Forlì, Forlì Cesena, Italy
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Water Team S.r.l., 47522 Cesena, Forlì Cesena, Italy
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Regional Reference Laboratory for Clinical Diagnosis of Legionellosis, Unit of Microbiology and Virology, Modena University Hospital, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(4), 209; https://doi.org/10.3390/pathogens8040209
Received: 27 September 2019 / Revised: 24 October 2019 / Accepted: 25 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Legionella Contamination in Water Environment)
Legionella surveillance is an important issue in public health, linked to the severity of disease and the difficulty associated with eradicating this bacterium from the water environment. Different treatments are suggested to reduce Legionella risk, however long-term studies of their efficiency are lacking. This study focused on the activity of a new formulation of hydrogen peroxide and silver salts, WTP828, in the hospital hot water network (HWN) to contain Legionella contamination during two years of treatment. The effectiveness of WTP828 was tested measuring physical-chemical and microbiological parameters such as Legionella, Pseudomonas aeruginosa (P. aeruginosa), and a heterotopic plate count (HPC) at 36 °C. Legionella isolates were identified by serotyping and genotyping. WTP 828 induced a reduction in Legionella–positive sites (60% to 36%) and contamination levels (2.12 to 1.7 log10 CFU/L), with isolates belonging to L. pneumophila SG1 (ST1 and ST104), L. anisa and L. rubrilucens widely distributed in HWN. No relevant contamination was found for other parameters tested. The long-term effect of WTP828 on Legionella containment suggest the easy and safe application of this disinfectant, that combined with knowledge of building characteristics, an adequate environmental monitoring and risk assessment plan, become the key elements in preventing Legionella contamination and exposure. View Full-Text
Keywords: WTP 828; Legionella; risk assessment plan; water quality; microbial analysis; chemical analysis WTP 828; Legionella; risk assessment plan; water quality; microbial analysis; chemical analysis
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Girolamini, L.; Dormi, A.; Pellati, T.; Somaroli, P.; Montanari, D.; Costa, A.; Savelli, F.; Martelli, A.; Grottola, A.; Fregni Serpini, G.; Cristino, S. Advances in Legionella Control by a New Formulation of Hydrogen Peroxide and Silver Salts in a Hospital Hot Water Network. Pathogens 2019, 8, 209.

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