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Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection

1
Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast BT9 7BL, Northern Ireland, UK
2
Department of Paediatric Respiratory Medicine, Royal Belfast Hospital for Sick Children, Belfast BT12 6BE, Northern Ireland, UK
*
Authors to whom correspondence should be addressed.
Pathogens 2019, 8(3), 106; https://doi.org/10.3390/pathogens8030106
Received: 25 June 2019 / Revised: 16 July 2019 / Accepted: 17 July 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Virus-Host Interactions of Respiratory Syncytial Virus (RSV))
The airway epithelium is the primary target of respiratory syncytial virus infection. It is an important component of the antiviral immune response. It contributes to the recruitment and activation of innate immune cells from the periphery through the secretion of cytokines and chemokines. This paper provides a broad review of the cytokines and chemokines secreted from human airway epithelial cell models during respiratory syncytial virus (RSV) infection based on a comprehensive literature review. Epithelium-derived chemokines constitute most inflammatory mediators secreted from the epithelium during RSV infection. This suggests chemo-attraction of peripheral immune cells, such as monocytes, neutrophils, eosinophils, and natural killer cells as a key function of the epithelium. The reports of epithelium-derived cytokines are limited. Recent research has started to identify novel cytokines, the functions of which remain largely unknown in the wider context of the RSV immune response. It is argued that the correct choice of in vitro models used for investigations of epithelial immune functions during RSV infection could facilitate greater progress in this field. View Full-Text
Keywords: respiratory syncytial virus; airway epithelium; innate immunity; inflammatory mediators; cytokines; chemokines respiratory syncytial virus; airway epithelium; innate immunity; inflammatory mediators; cytokines; chemokines
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MDPI and ACS Style

Glaser, L.; Coulter, P.J.; Shields, M.; Touzelet, O.; Power, U.F.; Broadbent, L. Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection. Pathogens 2019, 8, 106. https://doi.org/10.3390/pathogens8030106

AMA Style

Glaser L, Coulter PJ, Shields M, Touzelet O, Power UF, Broadbent L. Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection. Pathogens. 2019; 8(3):106. https://doi.org/10.3390/pathogens8030106

Chicago/Turabian Style

Glaser, Lena, Patricia J. Coulter, Michael Shields, Olivier Touzelet, Ultan F. Power, and Lindsay Broadbent. 2019. "Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection" Pathogens 8, no. 3: 106. https://doi.org/10.3390/pathogens8030106

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