Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector

Liu, Guodong; Cao, Wenguang; Salawudeen, Abdjeleel; Zhu, Wenjun; Emeterio, Karla; Safronetz, David; Banadyga, Logan

doi:10.3390/pathogens10091092

Open AccessReview

Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector

by

Guodong Liu

^1,†

,

Wenguang Cao

^1,†,

Abdjeleel Salawudeen

²,

Wenjun Zhu

³,

Karla Emeterio

^1,2,

David Safronetz

^1,2,* and

Logan Banadyga

^1,*

¹

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada

²

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada

³

Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB R3E 3M4, Canada

^*

Authors to whom correspondence should be addressed.

^†

Guodong Liu and Wenguang Cao contributed equally to this manuscript.

Pathogens 2021, 10(9), 1092; https://doi.org/10.3390/pathogens10091092

Submission received: 30 July 2021 / Revised: 23 August 2021 / Accepted: 25 August 2021 / Published: 27 August 2021

(This article belongs to the Special Issue Vesicular Stomatitis Virus: Agricultural Pathogen and Human Medical Research Tool)

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Abstract

Vesicular stomatitis virus (VSV), which belongs to the Vesiculovirus genus of the family Rhabdoviridae, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. Although VSV is responsible for causing economically significant outbreaks of vesicular stomatitis in cattle, horses, and swine, the virus also represents a valuable research tool for molecular biologists and virologists. Indeed, the establishment of a reverse genetics system for the recovery of infectious VSV from cDNA transformed the utility of this virus and paved the way for its use as a vaccine vector. A highly effective VSV-based vaccine against Ebola virus recently received clinical approval, and many other VSV-based vaccines have been developed, particularly for high-consequence viruses. This review seeks to provide a holistic but concise overview of VSV, covering the virus’s ascension from perennial agricultural scourge to promising medical countermeasure, with a particular focus on vaccines.

Keywords: vesicular stomatitis virus; VSV; vaccine; countermeasure; Ebola virus; VSV-EBOV; reverse genetics; medical countermeasure

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MDPI and ACS Style

Liu, G.; Cao, W.; Salawudeen, A.; Zhu, W.; Emeterio, K.; Safronetz, D.; Banadyga, L. Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector. Pathogens 2021, 10, 1092. https://doi.org/10.3390/pathogens10091092

AMA Style

Liu G, Cao W, Salawudeen A, Zhu W, Emeterio K, Safronetz D, Banadyga L. Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector. Pathogens. 2021; 10(9):1092. https://doi.org/10.3390/pathogens10091092

Chicago/Turabian Style

Liu, Guodong, Wenguang Cao, Abdjeleel Salawudeen, Wenjun Zhu, Karla Emeterio, David Safronetz, and Logan Banadyga. 2021. "Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector" Pathogens 10, no. 9: 1092. https://doi.org/10.3390/pathogens10091092

APA Style

Liu, G., Cao, W., Salawudeen, A., Zhu, W., Emeterio, K., Safronetz, D., & Banadyga, L. (2021). Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector. Pathogens, 10(9), 1092. https://doi.org/10.3390/pathogens10091092

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector

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