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Open AccessArticle

Staphylococcus saccharolyticus Associated with Prosthetic Joint Infections: Clinical Features and Genomic Characteristics

1
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, 701 82 Örebro, Sweden
2
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, 701 85 Örebro, Sweden
3
Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark
4
Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, University of Göttingen, 37077 Göttingen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Jilei Zhang
Pathogens 2021, 10(4), 397; https://doi.org/10.3390/pathogens10040397
Received: 22 February 2021 / Revised: 18 March 2021 / Accepted: 22 March 2021 / Published: 26 March 2021
(This article belongs to the Special Issue Staphylococcus Infections in Humans and Animals)
The anaerobic coagulase-negative staphylococcal species Staphylococcus saccharolyticus is a member of the normal skin microbiota. However, S. saccharolyticus is rarely found in clinical specimens and its pathogenic potential is unclear. The clinical data of prosthetic hip (n = 5) and shoulder (n = 2) joint implant-associated infections where S. saccharolyticus was detected in periprosthetic tissue specimens are described. The prosthetic hip joint infection cases presented as “aseptic” loosening and may represent chronic, insidious, low-grade prosthetic joint infections (PJIs), eventually resulting in loosening of prosthetic components. All cases were subjected to one-stage revision surgery and the long-term outcome was good. The shoulder joint infections had an acute onset. Polymicrobial growth, in all cases with Cutibacterium acnes, was found in 4/7 patients. All but one case were treated with long-term administration of beta-lactam antibiotics. Whole-genome sequencing (WGS) of the isolates was performed and potential virulence traits were identified. WGS could distinguish two phylogenetic clades (clades 1 and 2), which likely represent distinct subspecies of S. saccharolyticus. Little strain individuality was observed among strains from the same clade. Strains of clade 2 were exclusively associated with hip PJIs, whereas clade 1 strains originated from shoulder PJIs. It is possible that strains of the two clades colonize different skin habitats. In conclusion, S. saccharolyticus has the potential to cause PJIs that were previously regarded as aseptic loosening of prosthetic joint devices. View Full-Text
Keywords: Staphylococcus saccharolyticus; coagulase-negative staphylococci; whole-genome sequencing; prosthetic joint infections Staphylococcus saccharolyticus; coagulase-negative staphylococci; whole-genome sequencing; prosthetic joint infections
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MDPI and ACS Style

Söderquist, B.; Afshar, M.; Poehlein, A.; Brüggemann, H. Staphylococcus saccharolyticus Associated with Prosthetic Joint Infections: Clinical Features and Genomic Characteristics. Pathogens 2021, 10, 397. https://doi.org/10.3390/pathogens10040397

AMA Style

Söderquist B, Afshar M, Poehlein A, Brüggemann H. Staphylococcus saccharolyticus Associated with Prosthetic Joint Infections: Clinical Features and Genomic Characteristics. Pathogens. 2021; 10(4):397. https://doi.org/10.3390/pathogens10040397

Chicago/Turabian Style

Söderquist, Bo; Afshar, Mastaneh; Poehlein, Anja; Brüggemann, Holger. 2021. "Staphylococcus saccharolyticus Associated with Prosthetic Joint Infections: Clinical Features and Genomic Characteristics" Pathogens 10, no. 4: 397. https://doi.org/10.3390/pathogens10040397

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