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Epigenomes 2017, 1(3), 15; https://doi.org/10.3390/epigenomes1030015

EHMT1/GLP; Biochemical Function and Association with Brain Disorders

MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK
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Academic Editors: Guoping Fan and Che‐Kun James Shen
Received: 6 October 2017 / Revised: 10 October 2017 / Accepted: 11 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Epigenetics of the Nervous System)
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Abstract

The gene EHMT1 that encodes the Euchromatic Histone Methyltransferase-1, also known as GLP (G9a-like protein), has been associated with a number of neurodevelopmental and neurodegenerative disorders. GLP is a member of the euchromatic lysine histone methyltransferase family, along with EHMT2 or G9A. As its name implies, Ehmt1/GLP is involved in the addition of methyl groups to histone H3 lysine 9, a generally repressive mark linked to classical epigenetic process such as genomic imprinting, X-inactivation, and heterochromatin formation. However, GLP also plays both a direct and indirect role in regulating DNA-methylation. Here, we discuss what is currently known about the biochemical function of Ehmt1/GLP and its association, via various genetic studies, with brain disorders. View Full-Text
Keywords: Ehmt1/GLP; G9a; histone methyltransferase; DNA methylation; neurodevelopment; neurodegeneration Ehmt1/GLP; G9a; histone methyltransferase; DNA methylation; neurodevelopment; neurodegeneration
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Adam, M.A.; Isles, A.R. EHMT1/GLP; Biochemical Function and Association with Brain Disorders. Epigenomes 2017, 1, 15.

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