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Epigenomes 2017, 1(3), 15;

EHMT1/GLP; Biochemical Function and Association with Brain Disorders

MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK
Author to whom correspondence should be addressed.
Academic Editors: Guoping Fan and Che‐Kun James Shen
Received: 6 October 2017 / Revised: 10 October 2017 / Accepted: 11 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Epigenetics of the Nervous System)
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The gene EHMT1 that encodes the Euchromatic Histone Methyltransferase-1, also known as GLP (G9a-like protein), has been associated with a number of neurodevelopmental and neurodegenerative disorders. GLP is a member of the euchromatic lysine histone methyltransferase family, along with EHMT2 or G9A. As its name implies, Ehmt1/GLP is involved in the addition of methyl groups to histone H3 lysine 9, a generally repressive mark linked to classical epigenetic process such as genomic imprinting, X-inactivation, and heterochromatin formation. However, GLP also plays both a direct and indirect role in regulating DNA-methylation. Here, we discuss what is currently known about the biochemical function of Ehmt1/GLP and its association, via various genetic studies, with brain disorders. View Full-Text
Keywords: Ehmt1/GLP; G9a; histone methyltransferase; DNA methylation; neurodevelopment; neurodegeneration Ehmt1/GLP; G9a; histone methyltransferase; DNA methylation; neurodevelopment; neurodegeneration

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Adam, M.A.; Isles, A.R. EHMT1/GLP; Biochemical Function and Association with Brain Disorders. Epigenomes 2017, 1, 15.

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