Epitranscriptome and FMRP Regulated mRNA Translation
Abstract
:1. Introduction
2. RNA Methylation and Neuronal Function
3. RNA Editing
4. Dendritic Local Translation and Neurological Disorders
5. Potential Roles of RNA Modifications in TDP-43/FMRP-Associated Neurological Diseases
Acknowledgments
Author Contributions
Conflicts of Interest
References
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RNA Modification | Base Involved | Occur in | Modification Enzyme/s |
---|---|---|---|
m6A | Adenosine | mRNA, tRNA | METTL3/METTl14 |
m5C | Cytosine | mRNA, tRNA, ncRNAs | NOP2/NOL1, YebU/Trm4, RsmB and NSun family proteins |
A-to-I conversion | Adenosine | mRNAs | Adenosine deaminases |
m6Am | Adenosine | mRNA | mRNA (2′-O-methyladenosine-N6-) methyltransferases |
Pseudouridylation | Uridine | ncRNA, mRNA | Ψ synthases |
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Majumder, P.; Chatterjee, B.; Shen, C.-K.J. Epitranscriptome and FMRP Regulated mRNA Translation. Epigenomes 2017, 1, 11. https://doi.org/10.3390/epigenomes1020011
Majumder P, Chatterjee B, Shen C-KJ. Epitranscriptome and FMRP Regulated mRNA Translation. Epigenomes. 2017; 1(2):11. https://doi.org/10.3390/epigenomes1020011
Chicago/Turabian StyleMajumder, Pritha, Biswanath Chatterjee, and C.-K. James Shen. 2017. "Epitranscriptome and FMRP Regulated mRNA Translation" Epigenomes 1, no. 2: 11. https://doi.org/10.3390/epigenomes1020011