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Epigenomes 2017, 1(2), 11; https://doi.org/10.3390/epigenomes1020011

Epitranscriptome and FMRP Regulated mRNA Translation

Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
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Authors to whom correspondence should be addressed.
These authors Contributed equally to this work.
Academic Editor: Muller Fabbri
Received: 18 May 2017 / Revised: 14 July 2017 / Accepted: 17 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Epigenetics of the Nervous System)
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Abstract

An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP). View Full-Text
Keywords: epitranscriptome; FMRP; TDP-43; RNA methylation; RNA editing; dendritic local translation; neurological diseases epitranscriptome; FMRP; TDP-43; RNA methylation; RNA editing; dendritic local translation; neurological diseases
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Majumder, P.; Chatterjee, B.; Shen, C.-K.J. Epitranscriptome and FMRP Regulated mRNA Translation. Epigenomes 2017, 1, 11.

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