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Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge

Northern Ireland Centre for Stratified Medicine, Altnagelvin Hospital Campus, Ulster University, Londonderry BT47 6SB, Northern Ireland, UK
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J. Pers. Med. 2018, 8(4), 44; https://doi.org/10.3390/jpm8040044
Received: 31 October 2018 / Revised: 27 November 2018 / Accepted: 5 December 2018 / Published: 13 December 2018
Multiple genes and mechanisms of pathophysiology have been implicated in amyotrophic lateral sclerosis (ALS), suggesting it is a complex systemic disease. With this in mind, applying personalized medicine (PM) approaches to tailor treatment pipelines for ALS patients may be necessary. The modelling and analysis of molecular interaction networks could represent valuable resources in defining ALS-associated pathways and discovering novel therapeutic targets. Here we review existing omics datasets and analytical approaches, in order to consider how molecular interaction networks could improve our understanding of the molecular pathophysiology of this fatal neuromuscular disorder. View Full-Text
Keywords: ALS; personalized medicine; molecular interaction networks ALS; personalized medicine; molecular interaction networks
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Morgan, S.; Duguez, S.; Duddy, W. Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge. J. Pers. Med. 2018, 8, 44.

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