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Case Report

A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature

by
Maria Filoftea Mercuț
1,†,
Oana Maria Ică
2,*,
Cornelia Andreea Tănasie
3,*,
Răzvan Mercuț
4,†,
Carmen Luminița Mocanu
1,
Andreea Mihaela Nicolcescu
5 and
Ciprian Danielescu
6
1
Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Dermatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Department of Plastic Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
5
Department of Ophthalmology, Clinical County Emergency Hospital, 200642 Craiova, Romania
6
Department of Ophthalmology, University of Medicine and Pharmacy Grigorie T. Popa Iasi, 700115 Iasi, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Pers. Med. 2024, 14(3), 235; https://doi.org/10.3390/jpm14030235
Submission received: 23 January 2024 / Revised: 12 February 2024 / Accepted: 19 February 2024 / Published: 22 February 2024
(This article belongs to the Section Personalized Therapy in Clinical Medicine)
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Abstract

Eales disease manifests as an obliterative periphlebitis affecting the retina; it originates from the periphery and progresses posteriorly. It is characterized by retinal vessel wall inflammation, ischemia, and retinal neovascularization. In this report, we present the case of a 34-year-old male who attended our clinic with a sudden blurring of vision in his right eye. A diagnosis of bilateral retinal vasculitis with vitreal hemorrhage was ascertained in his RE. A dilated ocular fundus examination revealed perivenous sheathing of the peripheral vessels in both eyes. Fluorescein angiography indicated dye staining, vessel obliteration, capillary drop-out, areas of non-perfusion and the formation of new vessels. Laboratory tests revealed positive results for Borrelia; a PPD skin test and QuantiFERON TB assay were also positive. The patient underwent bilateral retinal laser pan-photocoagulation, followed by systemic treatment with oral steroids, cephazoline, isoniazid, azathioprine, and entecavir. The steroid dose was progressively reduced over 10 months; the treatment with azathioprine continues, as we are monitoring the patient over the long term. After 3 months, the vasculitis had regressed without any vitreal hemorrhage recurrence. Vision acuity improved from 0.4 to 1 in the patient’s right eye. A multidisciplinary approach, which included collaborative management with gastroenterology, infectious disease, pulmonology, and rheumatology specialists, was essential for the diagnosis, treatment, and long-term follow up of the patient.
Keywords: Eales disease; Mycobacterium tuberculosis; epimacular membrane; retinal vasculitis Eales disease; Mycobacterium tuberculosis; epimacular membrane; retinal vasculitis

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MDPI and ACS Style

Mercuț, M.F.; Ică, O.M.; Tănasie, C.A.; Mercuț, R.; Mocanu, C.L.; Nicolcescu, A.M.; Danielescu, C. A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature. J. Pers. Med. 2024, 14, 235. https://doi.org/10.3390/jpm14030235

AMA Style

Mercuț MF, Ică OM, Tănasie CA, Mercuț R, Mocanu CL, Nicolcescu AM, Danielescu C. A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature. Journal of Personalized Medicine. 2024; 14(3):235. https://doi.org/10.3390/jpm14030235

Chicago/Turabian Style

Mercuț, Maria Filoftea, Oana Maria Ică, Cornelia Andreea Tănasie, Răzvan Mercuț, Carmen Luminița Mocanu, Andreea Mihaela Nicolcescu, and Ciprian Danielescu. 2024. "A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature" Journal of Personalized Medicine 14, no. 3: 235. https://doi.org/10.3390/jpm14030235

APA Style

Mercuț, M. F., Ică, O. M., Tănasie, C. A., Mercuț, R., Mocanu, C. L., Nicolcescu, A. M., & Danielescu, C. (2024). A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature. Journal of Personalized Medicine, 14(3), 235. https://doi.org/10.3390/jpm14030235

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