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Volume 13
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10.3390/jpm13010014
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Case Report

Genetic Predictors of the Development of Complications after Coronary Stenting

by
Dana Taizhanova
1,
Akerke Kalimbetova
1,*,
Roza Bodaubay
1,
Aliya Toleuova
1,
Rakhima Toiynbekova
1,
Zhazira Beysenbekova
1,
Olga Visternichan
1,
Zauresh Tauesheva
1,
Irina Kadyrova
1,
Dmitriy Babenko
1,
Lyudmila Akhmaltdinova
1,
Svetlana Kolesnichenko
1,
Yevgeniya Kolesnikova
1,
Olga V. Avdienko
2,
Ainur Akilzhanova
3 and
Grigorios T. Gerotziafas
4
1
Department of Internal Medicine Scientific and Research Center, Karaganda Medical University, Karaganda 100000, Kazakhstan
2
Shared Resource Laboratory, Scientific and Research Center, Karaganda Medical University, Karaganda 100000, Kazakhstan
3
National Laboratory Astana, Laboratory of Genomic and Personalized Medicine, Nazarbayev University, Astana 010000, Kazakhstan
4
Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine, Institut National de la Santé et de la Recherche Médicale, INSERM U938 and Faculté de Médecine Pierre et Marie Curie (UPMC), Sorbonne Universities, 75006 Paris, France
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2023, 13(1), 14; https://doi.org/10.3390/jpm13010014
Submission received: 11 November 2022 / Revised: 9 December 2022 / Accepted: 19 December 2022 / Published: 22 December 2022
(This article belongs to the Special Issue Cardiovascular Diseases—From Risk Factors to Diagnosis and Personalized Management)
Review Reports Versions Notes

Abstract

Due to the fact that there are scientific discussions about the significance of gene polymorphisms in the risk of developing cardiovascular complications after a percutaneous coronary intervention, it is of interest to evaluate the genetic predictors of the development of cardiovascular events. This study is a molecular genetic study. Association with the genes of biomarkers for inflammation and immune response increases the risk of cardiovascular events: rs1234313 (TNFSF4): (A/G, OR-4.57 (2.35–8.87), p ≤ 0.0001), (A/G-A/A, OR-3.14 (1.75–5.63), p ≤ 0.0001), and (A/G, OR = 4.01 (2.19–7.36), p ≤ 0.0001); rs3184504 (SH2D3); ATXN2: (C/T, OR-2.53 (1.28–5.01), T/T, OR-2.99 (1.13–7.92), p = 0.017)), (C/T-T/T, OR-2.61 (1.35–5.07), p = 0.000), and (OR-1.89 (1.15–3.09), p = 0.009)). According to the lipid metabolism biomarker genes, rs2943634: (A/C OR-2.57 (1.18–5.62), p = 0.013); according to the endothelial biomarker genes, rs2713604: (DNAJB8-AS1; GATA2): (C/T, OR-4.27 (2.35–7.76), p ≤ 0.0001), (C/T-C/C, OR-4.13 (2.31–7.40), p ≤ 0.0001), (OR-4.05 (2.24–7.30), p ≤ 0.0001), and (C/T, OR-3.46 (1.99–6.00), p ≤ 0.0001). The regression analysis found that in the presence of the rs2943634 gene polymorphism, the risk of late cardiovascular events increases by 4.007 times with 95% CI (1.502:10.692), p = 0.006. The genes of biomarkers for the risk of cardiovascular events are rs1234313(TNFSF4), rs3184504 (SH2D3; ATXN2), rs2943634, and rs2713604 (DNAJB8-AS1; GATA2). The only predictor of the development of new cardiovascular events was rs2943634, which belongs to the group of lipid metabolism biomarkers.
Keywords: genetic predictors; risk factors; coronary stenting; complication genetic predictors; risk factors; coronary stenting; complication

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MDPI and ACS Style

Taizhanova, D.; Kalimbetova, A.; Bodaubay, R.; Toleuova, A.; Toiynbekova, R.; Beysenbekova, Z.; Visternichan, O.; Tauesheva, Z.; Kadyrova, I.; Babenko, D.; et al. Genetic Predictors of the Development of Complications after Coronary Stenting. J. Pers. Med. 2023, 13, 14. https://doi.org/10.3390/jpm13010014

AMA Style

Taizhanova D, Kalimbetova A, Bodaubay R, Toleuova A, Toiynbekova R, Beysenbekova Z, Visternichan O, Tauesheva Z, Kadyrova I, Babenko D, et al. Genetic Predictors of the Development of Complications after Coronary Stenting. Journal of Personalized Medicine. 2023; 13(1):14. https://doi.org/10.3390/jpm13010014

Chicago/Turabian Style

Taizhanova, Dana, Akerke Kalimbetova, Roza Bodaubay, Aliya Toleuova, Rakhima Toiynbekova, Zhazira Beysenbekova, Olga Visternichan, Zauresh Tauesheva, Irina Kadyrova, Dmitriy Babenko, and et al. 2023. "Genetic Predictors of the Development of Complications after Coronary Stenting" Journal of Personalized Medicine 13, no. 1: 14. https://doi.org/10.3390/jpm13010014

APA Style

Taizhanova, D., Kalimbetova, A., Bodaubay, R., Toleuova, A., Toiynbekova, R., Beysenbekova, Z., Visternichan, O., Tauesheva, Z., Kadyrova, I., Babenko, D., Akhmaltdinova, L., Kolesnichenko, S., Kolesnikova, Y., Avdienko, O. V., Akilzhanova, A., & Gerotziafas, G. T. (2023). Genetic Predictors of the Development of Complications after Coronary Stenting. Journal of Personalized Medicine, 13(1), 14. https://doi.org/10.3390/jpm13010014

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