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Volume 12
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10.3390/jpm12071118
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Communication

A Possible Link between Gut Microbiome Composition and Cardiovascular Comorbidities in Psoriatic Patients

by
Virginia Valentini
1,
Valentina Silvestri
1,
Agostino Bucalo
1,
Federica Marraffa
2,
Maria Risicato
2,
Sara Grassi
2,
Giovanni Pellacani
2,
Laura Ottini
1,* and
Antonio Giovanni Richetta
2
1
Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy
2
Unit of Dermatology, Department of Internal Medicine and Medical Specialties Sapienza, University of Rome, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(7), 1118; https://doi.org/10.3390/jpm12071118
Submission received: 10 May 2022 / Revised: 1 July 2022 / Accepted: 7 July 2022 / Published: 9 July 2022
(This article belongs to the Section Mechanisms of Diseases)
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Abstract

Cardiovascular disease (CVD) is one of the most common comorbidities that may affect psoriatic patients. Several exogenous and endogenous factors are involved in the etiology and progression of both psoriasis and CVD. A potential genetic link between the two diseases has emerged; however, some gaps remain in the understanding of the CVD prevalence in psoriatic patients. Recently, the role of the gut microbiome dysbiosis was documented in the development and maintenance of both diseases. To investigate whether gut microbiome dysbiosis might influence the occurrence of CVD in psoriatic patients, 16S rRNA gene sequencing was performed to characterize the gut microbiome of 28 psoriatic patients, including 17 patients with and 11 without CVD. The comparison of the gut microbiome composition between patients with and without CVD showed a higher prevalence of Barnesiellaceae and Phascolarctobacterium in patients with CVD. Among patients with CVD, those undergoing biologic therapy had lower abundance levels of Barnesiellaceae, comparable to those found in patients without CVD. Overall, these findings suggest that the co-occurrence of psoriasis and CVD might be linked to gut microbiome dysbiosis and that therapeutic strategies could help to restore the intestinal symbiosis, potentially improving the clinical management of psoriasis and its associated comorbidities.
Keywords: psoriasis; comorbidities; cardiovascular disease; gut microbiome; biologic therapy; 16S rRNA gene sequencing psoriasis; comorbidities; cardiovascular disease; gut microbiome; biologic therapy; 16S rRNA gene sequencing

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MDPI and ACS Style

Valentini, V.; Silvestri, V.; Bucalo, A.; Marraffa, F.; Risicato, M.; Grassi, S.; Pellacani, G.; Ottini, L.; Richetta, A.G. A Possible Link between Gut Microbiome Composition and Cardiovascular Comorbidities in Psoriatic Patients. J. Pers. Med. 2022, 12, 1118. https://doi.org/10.3390/jpm12071118

AMA Style

Valentini V, Silvestri V, Bucalo A, Marraffa F, Risicato M, Grassi S, Pellacani G, Ottini L, Richetta AG. A Possible Link between Gut Microbiome Composition and Cardiovascular Comorbidities in Psoriatic Patients. Journal of Personalized Medicine. 2022; 12(7):1118. https://doi.org/10.3390/jpm12071118

Chicago/Turabian Style

Valentini, Virginia, Valentina Silvestri, Agostino Bucalo, Federica Marraffa, Maria Risicato, Sara Grassi, Giovanni Pellacani, Laura Ottini, and Antonio Giovanni Richetta. 2022. "A Possible Link between Gut Microbiome Composition and Cardiovascular Comorbidities in Psoriatic Patients" Journal of Personalized Medicine 12, no. 7: 1118. https://doi.org/10.3390/jpm12071118

APA Style

Valentini, V., Silvestri, V., Bucalo, A., Marraffa, F., Risicato, M., Grassi, S., Pellacani, G., Ottini, L., & Richetta, A. G. (2022). A Possible Link between Gut Microbiome Composition and Cardiovascular Comorbidities in Psoriatic Patients. Journal of Personalized Medicine, 12(7), 1118. https://doi.org/10.3390/jpm12071118

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