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Article

Exposure to Proton Pump Inhibitors and the Risk of Incident Asthma in Patients with Coronary Artery Diseases: A Population-Based Cohort Study

by
Tsung-Kun Lin
1,2,†,
Chin-Feng Tsai
3,4,
Jing-Yang Huang
4,5,
Lung-Fa Pan
6,7,† and
Gwo-Ping Jong
3,4,*
1
Department of Pharmacy, Taoyuan Armed Forces General Hospital, Taoyuan 32551, Taiwan
2
School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan
3
Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
4
School of Medicine and Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
5
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
6
Graduate Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung 40653, Taiwan
7
Department of Cardiology, Taichung Armed Forces General Hospital, Taichung 41168, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Pers. Med. 2022, 12(5), 824; https://doi.org/10.3390/jpm12050824
Submission received: 24 April 2022 / Revised: 12 May 2022 / Accepted: 17 May 2022 / Published: 19 May 2022
(This article belongs to the Special Issue Personalized Medicine in Cardiovascular Diseases)
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Abstract

We aimed to determine the association between proton pump inhibitor (PPI) use and incident asthma in patients with coronary artery disease (CAD). This nationwide cohort study collected claims data from the Taiwanese Bureau of National Health Insurance from 2004 to 2013. The primary outcome, i.e., the risk of incident asthma, was assessed by estimating hazard ratios (HRs) and 95% confidence intervals (CIs). The adjusted HR of asthma development was estimated using the Cox regression model. Sensitivity and subgroup analyses were also conducted. A total of 8894 PPI users and 12,684 H2-receptor antagonist (H2RA) users were included in patients with CAD. Compared with H2RA use, an increased risk of incident asthma was found between PPI use and the risk of incident asthma in patients with CAD after adjusting for sex, age, urbanization, and low income (HR: 1.41; 95% CI: 1.04–1.89). The sensitivity analysis results were consistent with the main analysis results. However, the subgroup analysis revealed no association of incident asthma in patients with diabetes mellitus, hyperlipidemia, stroke, allergic rhinitis, pneumonia, cancer, or depression in the PPI group compared with those in the H2RA group. In conclusion, PPI use increased the risk of asthma development in patients with CAD.
Keywords: proton pump inhibitors; coronary artery disease; asthma; peptic ulcer disease proton pump inhibitors; coronary artery disease; asthma; peptic ulcer disease

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MDPI and ACS Style

Lin, T.-K.; Tsai, C.-F.; Huang, J.-Y.; Pan, L.-F.; Jong, G.-P. Exposure to Proton Pump Inhibitors and the Risk of Incident Asthma in Patients with Coronary Artery Diseases: A Population-Based Cohort Study. J. Pers. Med. 2022, 12, 824. https://doi.org/10.3390/jpm12050824

AMA Style

Lin T-K, Tsai C-F, Huang J-Y, Pan L-F, Jong G-P. Exposure to Proton Pump Inhibitors and the Risk of Incident Asthma in Patients with Coronary Artery Diseases: A Population-Based Cohort Study. Journal of Personalized Medicine. 2022; 12(5):824. https://doi.org/10.3390/jpm12050824

Chicago/Turabian Style

Lin, Tsung-Kun, Chin-Feng Tsai, Jing-Yang Huang, Lung-Fa Pan, and Gwo-Ping Jong. 2022. "Exposure to Proton Pump Inhibitors and the Risk of Incident Asthma in Patients with Coronary Artery Diseases: A Population-Based Cohort Study" Journal of Personalized Medicine 12, no. 5: 824. https://doi.org/10.3390/jpm12050824

APA Style

Lin, T.-K., Tsai, C.-F., Huang, J.-Y., Pan, L.-F., & Jong, G.-P. (2022). Exposure to Proton Pump Inhibitors and the Risk of Incident Asthma in Patients with Coronary Artery Diseases: A Population-Based Cohort Study. Journal of Personalized Medicine, 12(5), 824. https://doi.org/10.3390/jpm12050824

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