Sex-Specific Differences in Pre-Stroke Characteristics Reveal Vulnerability of Elderly Women
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Living Situation
3.2. Pre-Stroke Disability
3.3. Risk Factors
3.4. Cerebral and Cardiac Vascular Premorbidity
3.5. Stroke Etiology
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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≤30 | >30 and ≤50 | >50 and ≤70 | >70 and ≤90 | >90 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | |
Risk Factor | |||||||||||||||
Hypertension, n (%) | 3 (10.3) | 3 (5.0) | 0.387 [0.46] | 229 (44.6) | 116 (39.3) | 0.141 [0.80] | 1945 (76.7) | 897 (78.2) | 0.303 [1.09] | 2570 (86.0) | 2741 (88.8) | 0.001 ** [1.30] | 68 (87.2) | 237 (87.8) | 0.888 [1.06] |
Diabetes, n (%) | 0 (0.0) | 1 (1.7) | 1.000 [1.02] | 73 (14.2) | 30 (10.2) | 0.096 [0.68] | 766 (30.2) | 322 (28.1) | 0.192 [0.90] | 1021 (34.2) | 971 (31.5) | 0.026 * [0.88] | 17 (21.8) | 56 (20.7) | 0.840 [0.94] |
Hyperlipidemia, n (%) | 4 (13.8) | 4 (6.7) | 0.430 [0.45] | 150 (29.2) | 50 (16.9) | <0.001 *** [0.49] | 931 (36.7) | 427 (37.2) | 0.757 [1.02] | 1060 (35.5) | 1004 (32.5) | 0.016 * [0.88] | 18 (23.1) | 59 (21.9) | 0.818 [0.93] |
Smoking, n (%) | 10 (34.5) | 18 (30.0) | 0.669 [0.81] | 225 (43.9) | 119 (40.3) | 0.330 [0.86] | 790 (31.1) | 298 (26.0) | 0.001 ** [0.78] | 239 (8.0) | 131 (4.2) | <0.001 *** [0.51] | 1 (1.3) | 3 (1.1) | 1.000 [0.86] |
Premorbidity | |||||||||||||||
Stroke, n (%) | 1 (3.4) | 4 (6.7) | 1.000 [2.00] | 45 (8.8) | 20 (6.8) | 0.316 [0.76] | 418 (16.5) | 198 (17.3) | 0.554 [1.06] | 725 (24.3) | 658 (21.3) | 0.007 ** [0.85] | 14 (17.9) | 65 (24.1) | 0.255 [1.45] |
Heart Attack, n (%) | 1 (3.4) | 0 (0.0) | 0.326 [0.97] | 19 (3.7) | 5 (1.7) | 0.105 [0.45] | 235 (9.3) | 48 (4.2) | <0.001 *** [0.43] | 365 (12.2) | 204 (6.6) | <0.001 *** [0.51] | 8 (10.3) | 21 (7.8) | 0.485 [0.74] |
Atrial Fibrillation, n (%) | 0 (0.0) | 1 (1.7) | 1.000 [1.02] | 17 (3.3) | 7 (2.4) | 0.448 [0.71] | 336 (13.2) | 156 (13.6) | 0.768 [1.03] | 927 (31.0) | 1211 (39.3) | <0.001 *** [1.44] | 45 (57.7) | 149 (55.2) | 0.695 [0.90] |
Coronary Heart Disease, n (%) | 0 (0.0) | 0 (0.0) | - | 25 (4.9) | 3 (1.0) | 0.004 ** [0.20] | 328 (12.9) | 88 (7.7) | <0.001 *** [0.56] | 636 (21.3) | 376 (12.2) | <0.001 *** [0.51] | 12 (15.4) | 33 (12.2) | 0.463 [0.77] |
≤30 | >30 and ≤50 | >50 and ≤70 | >70 and ≤90 | >90 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | Men | Women | p-Value [OR] | |
Stroke Etiology | |||||||||||||||
Small Vessel Disease, n (%) | 3 (10.3) | 5 (8.3) | 0.712 [0.79] | 113 (22.0) | 64 (21.7) | 0.912 [0.98] | 668 (26.3) | 283 (24.7) | 0.287 [0.92] | 566 (18.9) | 518 (16.8) | 0.029 * [0.86] | 7 (9.0) | 25 (9.3) | 0.939 [1.03] |
Atherosclerosis, n (%) | 3 (10.3) | 8 (13.3) | 1.000 [1.33] | 99 (19.3) | 54 (18.3) | 0.729 [0.94] | 517 (20.4) | 221 (19.3) | 0.435 [0.93] | 564 (18.9) | 380 (12.3) | <0.001 *** [0.60] | 3 (3.8) | 19 (7.0) | 0.431 [1.89] |
Cardiac Source, n (%) | 4 (13.8) | 12 (20.0) | 0.475 [1.56] | 77 (15.0) | 35 (11.9) | 0.213 [0.76] | 558 (22.0) | 245 (21.4) | 0.666 [0.96] | 1057 (35.4) | 1347 (43.7) | <0.001 *** [1.42] | 48 (61.5) | 160 (59.3) | 0.718 [0.91] |
ESUS, n (%) | 6 (20.7) | 15 (25.0) | 0.654 [1.28] | 60 (11.7) | 36 (12.2) | 0.830 [1.05] | 280 (11.0) | 139 (12.1) | 0.338 [1.11] | 281 (9.4) | 295 (9.6) | 0.830 [1.02] | 6 (7.7) | 21 (7.8) | 0.980 [1.01] |
Other, n (%) | 7 (24.1) | 9 (15.0) | 0.293 [0.55] | 59 (11.5) | 52 (17.6) | 0.015 * [1.65] | 140 (5.5) | 76 (6.6) | 0.185 [1.21] | 115 (3.8) | 103 (3.3) | 0.287 [0.86] | 1 (1.3) | 3 (1.1) | 1.000 [0.86] |
Unidentified Cause, n (%) | 6 (20.7) | 11 (18.3) | 0.791 [0.86] | 105 (20.5) | 54 (18.3) | 0.457 [0.87] | 374 (14.7) | 183 (16.0) | 0.341 [1.10] | 406 (13.6) | 442 (14.3) | 0.403 [1.06] | 13 (16.7) | 42 (15.6) | 0.813 [0.92] |
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Hoyer, C.; Schlenker, J.; Sandikci, V.; Ebert, A.; Wittayer, M.; Platten, M.; Szabo, K. Sex-Specific Differences in Pre-Stroke Characteristics Reveal Vulnerability of Elderly Women. J. Pers. Med. 2022, 12, 344. https://doi.org/10.3390/jpm12030344
Hoyer C, Schlenker J, Sandikci V, Ebert A, Wittayer M, Platten M, Szabo K. Sex-Specific Differences in Pre-Stroke Characteristics Reveal Vulnerability of Elderly Women. Journal of Personalized Medicine. 2022; 12(3):344. https://doi.org/10.3390/jpm12030344
Chicago/Turabian StyleHoyer, Carolin, Jan Schlenker, Vesile Sandikci, Anne Ebert, Matthias Wittayer, Michael Platten, and Kristina Szabo. 2022. "Sex-Specific Differences in Pre-Stroke Characteristics Reveal Vulnerability of Elderly Women" Journal of Personalized Medicine 12, no. 3: 344. https://doi.org/10.3390/jpm12030344