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Volume 11
Issue 3
10.3390/jpm11030225
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Article

Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology

by
Mariana Tudoran
1,2,3,
Cristina Tudoran
1,2,*,
Voichita Elena Lazureanu
4,
Adelina Raluca Marinescu
4,
Gheorghe Nicusor Pop
5,
Alexandru Silvius Pescariu
5,
Alexandra Enache
6 and
Talida Georgiana Cut
4
1
Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania
2
Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041, Timisoara, Romania
3
County Emergency Hospital Timisoara, 300041 Timisoara, Romania
4
Department XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania
5
Department VI, Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania
6
Department VIII, Discipline of Forensic Medicine, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2021, 11(3), 225; https://doi.org/10.3390/jpm11030225
Submission received: 11 February 2021 / Revised: 1 March 2021 / Accepted: 17 March 2021 / Published: 22 March 2021
(This article belongs to the Special Issue COVID-19 Related Complications)
Versions Notes

Abstract

(1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diastolic dysfunction (DD) in COVID-19 patients without history of cardiovascular (CV) diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during the first outbreak of Covid-19 for moderate pneumonia, underwent a comprehensive cardiologic examination and TTE at 6–10 weeks after discharge. Their initial in-hospital laboratory data and thorax computer tomography (TCT) were accessed from the electronic database of the hospital. (3) Results: with TTE, we documented alterations of LV-SF and DD in 8.8% of patients and in 16.8% only patterns of DD, statistically correlated with the initial levels of creatin-kinase (CK-MB) and inflammatory factors. Multivariate regression analysis evidenced that CK-MB levels, age, and body mass index (BMI) are responsible for 65% of LV-SF decrease. (4) Conclusions: Alterations of LV-SF and DD are frequent in post-acute COVID-19 infection and are responsible for the persistence of symptoms. Elevated myocardial necrosis markers during the acute phase seem to predict subsequent alteration of cardiac performance.
Keywords: COVID-19; heart failure; inflammation; cytokine storm; transthoracic echocardio-graphy; left ventricular systolic dysfunction; diastolic dysfunction COVID-19; heart failure; inflammation; cytokine storm; transthoracic echocardio-graphy; left ventricular systolic dysfunction; diastolic dysfunction

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MDPI and ACS Style

Tudoran, M.; Tudoran, C.; Lazureanu, V.E.; Marinescu, A.R.; Pop, G.N.; Pescariu, A.S.; Enache, A.; Cut, T.G. Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology. J. Pers. Med. 2021, 11, 225. https://doi.org/10.3390/jpm11030225

AMA Style

Tudoran M, Tudoran C, Lazureanu VE, Marinescu AR, Pop GN, Pescariu AS, Enache A, Cut TG. Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology. Journal of Personalized Medicine. 2021; 11(3):225. https://doi.org/10.3390/jpm11030225

Chicago/Turabian Style

Tudoran, Mariana, Cristina Tudoran, Voichita Elena Lazureanu, Adelina Raluca Marinescu, Gheorghe Nicusor Pop, Alexandru Silvius Pescariu, Alexandra Enache, and Talida Georgiana Cut. 2021. "Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology" Journal of Personalized Medicine 11, no. 3: 225. https://doi.org/10.3390/jpm11030225

APA Style

Tudoran, M., Tudoran, C., Lazureanu, V. E., Marinescu, A. R., Pop, G. N., Pescariu, A. S., Enache, A., & Cut, T. G. (2021). Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology. Journal of Personalized Medicine, 11(3), 225. https://doi.org/10.3390/jpm11030225

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