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Open AccessArticle

Laser Doppler Spectrum Analysis Based on Calculation of Cumulative Sums Detects Changes in Skin Capillary Blood Flow in Type 2 Diabetes Mellitus

1
Research and Development Center of Biomedical Photonics, Orel State University, 302026 Orel, Russia
2
Optoelectronics and Measurement Techniques Unit, University of Oulu, 90570 Oulu, Finland
3
Orel Regional Clinical Hospital, 302028 Orel, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Xavier Muñoz-Berbel
Diagnostics 2021, 11(2), 267; https://doi.org/10.3390/diagnostics11020267
Received: 1 December 2020 / Revised: 31 January 2021 / Accepted: 3 February 2021 / Published: 9 February 2021
(This article belongs to the Special Issue Optical Diagnostics in Human Diseases)
In this article, we introduce a new method of signal processing and data analysis for the digital laser Doppler flowmetry. Our approach is based on the calculation of cumulative sums over the registered Doppler power spectra. The introduced new parameter represents an integral estimation for the redistribution of moving red blood cells over the range of speed. The prototype of the device implementing the technique is developed and tested in preliminary clinical trials. The methodology was verified with the involvement of two age groups of healthy volunteers and in a group of patients with type 2 diabetes mellitus. The main practical result of the study is the development of a set of binary linear classifiers that allow the method to identify typical patterns of the microcirculation for the healthy volunteers and diabetic patients based on the presented diagnostic algorithm. View Full-Text
Keywords: laser Doppler flowmetry; non-invasive optical diagnostics; cumulative sum; power spectrum; heating test; diabetes mellitus type 2 laser Doppler flowmetry; non-invasive optical diagnostics; cumulative sum; power spectrum; heating test; diabetes mellitus type 2
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MDPI and ACS Style

Kozlov, I.; Zherebtsov, E.; Masalygina, G.; Podmasteryev, K.; Dunaev, A. Laser Doppler Spectrum Analysis Based on Calculation of Cumulative Sums Detects Changes in Skin Capillary Blood Flow in Type 2 Diabetes Mellitus. Diagnostics 2021, 11, 267. https://doi.org/10.3390/diagnostics11020267

AMA Style

Kozlov I, Zherebtsov E, Masalygina G, Podmasteryev K, Dunaev A. Laser Doppler Spectrum Analysis Based on Calculation of Cumulative Sums Detects Changes in Skin Capillary Blood Flow in Type 2 Diabetes Mellitus. Diagnostics. 2021; 11(2):267. https://doi.org/10.3390/diagnostics11020267

Chicago/Turabian Style

Kozlov, Igor; Zherebtsov, Evgeny; Masalygina, Galina; Podmasteryev, Konstantin; Dunaev, Andrey. 2021. "Laser Doppler Spectrum Analysis Based on Calculation of Cumulative Sums Detects Changes in Skin Capillary Blood Flow in Type 2 Diabetes Mellitus" Diagnostics 11, no. 2: 267. https://doi.org/10.3390/diagnostics11020267

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