Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors
1
National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation, Petroverigsky 10, 101990 Moscow, Russia
2
Russian Federation State Research Center, Institute of Biomedical Problems of the Russian Academy of Sciences, Khoroshevskoe Highway 76A, 123007 Moscow, Russia
3
Orel State University, Komsomolskaya 95, 302026 Orel, Russia
4
Optoelectronics and Measurement Techniques, University of Oulu, Erkki Koiso-Kanttilankatu 3, 90014 Oulu, Finland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Xavier Muñoz-Berbel
Diagnostics 2021, 11(3), 436; https://doi.org/10.3390/diagnostics11030436
Received: 31 January 2021 / Revised: 24 February 2021 / Accepted: 24 February 2021 / Published: 4 March 2021
(This article belongs to the Special Issue Optical Diagnostics in Human Diseases)
In this study we demonstrate what kind of relative alterations can be expected in average perfusion and blood flow oscillations during postural changes being measured in the skin of limbs and on the brow of the forehead by wearable laser Doppler flowmetry (LDF) sensors. The aims of the study were to evaluate the dynamics of cutaneous blood perfusion and the regulatory mechanisms of blood microcirculation in the areas of interest, and evaluate the possible significance of those effects for the diagnostics based on blood perfusion monitoring. The study involved 10 conditionally healthy volunteers (44 ± 12 years). Wearable laser Doppler flowmetry monitors were fixed at six points on the body: two devices were fixed on the forehead, on the brow; two were on the distal thirds of the right and left forearms; and two were on the distal thirds of the right and left lower legs. The protocol was used to record three body positions on the tilt table for orthostatic test for each volunteer in the following sequence: (a) supine body position; (b) upright body position (+75°); (c) tilted with the feet elevated above the head and the inclination of body axis of 15° (−15°, Trendelenburg position). Skin blood perfusion was recorded for 10 min in each body position, followed by the amplitude–frequency analysis of the registered signals using wavelet decomposition. The measurements were supplemented with the blood pressure and heart rate for every body position analysed. The results identified a statistically significant transformation in microcirculation parameters of the average level of skin blood perfusion and oscillations of amplitudes of neurogenic, myogenic and cardiac sensors caused by the postural changes. In paper, we present the analysis of microcirculation in the skin of the forehead, which for the first time was carried out in various positions of the body. The area is supplied by the internal carotid artery system and can be of particular interest for evaluation of the sufficiency of blood supply for the brain.
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Keywords:
wearable blood flow sensors; blood perfusion; laser Doppler flowmetry; ortostatic test; postural changes; body position; blood perfusion in forehead; blood perfusion in wrists; blood perfusion in shins; blood perfusion oscillations; vasomotions
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MDPI and ACS Style
Fedorovich, A.A.; Loktionova, Y.I.; Zharkikh, E.V.; Mikhailova, M.A.; Popova, J.A.; Suvorov, A.V.; Zherebtsov, E.A. Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors. Diagnostics 2021, 11, 436. https://doi.org/10.3390/diagnostics11030436
AMA Style
Fedorovich AA, Loktionova YI, Zharkikh EV, Mikhailova MA, Popova JA, Suvorov AV, Zherebtsov EA. Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors. Diagnostics. 2021; 11(3):436. https://doi.org/10.3390/diagnostics11030436
Chicago/Turabian StyleFedorovich, Andrey A.; Loktionova, Yulia I.; Zharkikh, Elena V.; Mikhailova, Maria A.; Popova, Julia A.; Suvorov, Alexander V.; Zherebtsov, Evgeny A. 2021. "Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors" Diagnostics 11, no. 3: 436. https://doi.org/10.3390/diagnostics11030436
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